CardioVascular and Interventional Radiology

, Volume 29, Issue 3, pp 413–419 | Cite as

Long-Term Histopathologic and IVUS Evaluations of a Novel Coiled Sheet Stent in Porcine Carotid Arteries

  • Hideaki Kaneda
  • Fumiaki Ikeno
  • Jennifer Lyons
  • Mehrdad Rezaee
  • Alan C. Yeung
  • Peter J. Fitzgerald
Article

Abstract

Carotid angioplasty with stent placement has been proposed as an alternative method for revascularization of carotid artery stenosis. A novel stent with a laser-cut, rolled sheet of Nitinol (EndoTex Interventional Systems, Inc., Cupertino, CA) has been developed to customize treatment of stenotic lesions in carotid arteries utilizing a single stent, designed to adapt to multiple diameters and to tapered or nontapered configurations. The purpose of this study is to evaluate the conformability and vascular response to a novel stent in a chronic porcine carotid model using serial three-dimensional intravascular ultrasound (IVUS) analysis as well as histological examination. Ten Yucatan pigs underwent stent implantation in both normal carotid arteries with adjunctive balloon angioplasty. Three-dimensional IVUS analysis was performed before stent implantation, after adjunctive balloon angioplasty, and at follow-up [1 month (n = 6), 3 months (n = 6), or 6 months (n = 8)]. Histological examination (injury score, percent plaque obstruction, and qualitative analysis) was also performed. All stents were successfully deployed and well apposed in different sized vessels (lumen area range: 19–30 mm2). Volumetric IVUS analysis showed no significant difference between the lumen areas before stent implantation and after adjunctive balloon angioplasty and no stent area change at each follow-up point compared to immediately postprocedure. Histological examination revealed minimal injury and neointimal hyperplasia at each follow-up point. In the chronic porcine carotid model, the novel stent system demonstrated good conformability, resulting in minimal vessel injury and neointimal formation.

Keywords

Angioplasty Cerebrovascular accident Stents and prostheses 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Hideaki Kaneda
    • 1
  • Fumiaki Ikeno
    • 1
  • Jennifer Lyons
    • 1
  • Mehrdad Rezaee
    • 1
  • Alan C. Yeung
    • 1
  • Peter J. Fitzgerald
    • 1
  1. 1.Division of Cardiovascular MedicineStanford University Medical CenterStanfordUSA

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