World Journal of Surgery

, Volume 24, Issue 1, pp 17–21 | Cite as

Altered Bile Composition in the Gallbladder and Common Bile Duct of Patients with Anomalous Pancreaticobiliary Ductal Junction

  • Yuzuru Sugiyama
  • Hiroyasu Kobori
  • Kenichi Hakamada
  • Dai Seito
  • Mutsuo Sasaki
Article

Abstract

The high incidence of biliary tract carcinoma in patients with anomalous pancreaticobiliary ductal junction (APBDJ) has been well documented. Elevation of the secondary and free bile acid (FBA) concentrations is considered a risk factor for biliary carcinogenesis in these patients. Bile from the gallbladder and common bile duct in 12 patients with APBDJ was analyzed and compared with gallbladder bile from 19 patients with gastric cancer and a normal hepatobiliary tract. The concentrations of secondary bile acids were significantly lower in the APBDJ group than in the control group, and FBA concentrations were not detected in the gallbladder in either group. The lysolecithin (LL) in the phospholipid, which is produced from lecithin by activated phospholipase A2 in refluxing pancreatic juice, was significantly elevated in the APBDJ group. Elevation of the LL concentration in the bile is one of the factors for the development of biliary tract carcinoma in patients with APBDJ.

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Copyright information

© by the Société Internationale de Chirurgie 2000

Authors and Affiliations

  • Yuzuru Sugiyama
    • 1
  • Hiroyasu Kobori
    • 2
  • Kenichi Hakamada
    • 3
  • Dai Seito
    • 3
  • Mutsuo Sasaki
    • 3
  1. 1.Department of Nursing, Hirosaki University School of Allied Medical Sciences, 66-1 Hon-cho, Hirosaki, Aomori-ken 036-8564, JapanJP
  2. 2.Department of Surgery, Aomori Municipal Hospital, 1-14-20 Katsuta, Aomori, Aomori-ken 030-0821, JapanJP
  3. 3.Second Department of Surgery, Hirosaki University School of Medicine, 53 Hon-cho, Hirosaki, Aomori-ken 036-8563, JapanJP

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