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World Journal of Surgery

, Volume 23, Issue 10, pp 1045–1050 | Cite as

Pancreatic Solid-cystic-papillary Tumor: Clinicopathologic Features in Eight Patients from Hong Kong and Review of the Literature

  • King Y. Lam
  • Chung Y. Lo
  • Sheung T. Fan
Article

Abstract.

Solid-cystic-papillary tumors (SCPTs) of the pancreas are rare. The clinicopathologic features and pathogenesis of these tumors have attracted a number of investigations, but the results remain unclear. We investigated the clinicopathologic data, immunohistochemical expression of the pan-endocrine markers, hormones, steroid receptors, and p53 overexpression in pancreatic SCPTs from eight Chinese patients (seven women, one man) collected over a 24-year period. They accounted for 2.5% of the primary pancreatic tumors. The tumors were seen in young women (mean age 27 years). They were large (mean size of resected tumor was 8.4 cm), benign, had solid and cystic areas, and were evenly distributed in the pancreas. The main differential diagnosis was pancreatic endocrine tumor. The tumors were negative for pan-endocrine markers, hormones, estrogen receptor, progesterone receptor, and p53. To date, 452 pancreatic SCPTs have been documented in the English literature. They occurred in patients of different ethnic groups, particularly in non-Caucasians. The tumors were frequently noted in young females. Uncommon cases of malignant pancreatic SCPTs were often found in older men and had indolent behavior. It was concluded that pancreatic SCPTs have distinct clinicopathologic characteristics. The present observations, together with a review of the literature suggests that overexpression of p53 or estrogen receptor is not important in the pathogenesis of pancreatic SCPTs.

Keywords

Esophageal Squamous Cell Carcinoma Chinese Patient Cystic Tumor Islet Cell Tumor Main Differential Diagnosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Société Internationale de Chirugie 1999

Authors and Affiliations

  • King Y. Lam
    • 1
  • Chung Y. Lo
    • 2
  • Sheung T. Fan
    • 2
  1. 1.Department of Pathology, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, ChinaCN
  2. 2.Department of Surgery, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, ChinaCN

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