World Journal of Surgery

, Volume 21, Issue 7, pp 773–776 | Cite as

Close Correlation between Increased Sialyl-Lewisx Expression and Metastasis in Human Gastric Carcinoma

  • Hideki Ura
  • Ryuichi Denno
  • Koichi Hirata
  • Koji Yamaguchi
  • Takahiro Yasoshima
  • Takayuki Shishido

Abstract. Expression of sialyl-Lewisx (sLex) antigen was studied immunohistochemically in 110 resected human gastric carcinomas using an anti-sLex monoclonal antibody. Lymph node, liver, and peritoneal metastases were clearly more prevalent in tumors expressing high levels of sLex than in those with no or low-level sLex expression. No correlation was found between sLex expression and histologic grade or histologic type of the Lauren classification. Among the tumors with lymph node metastasis, 44% expressed high levels of sLex in both the primary tumor and involved lymph nodes, and 14% of the metastatic lesions demonstrated increased sLex expression. The 5-year survival rate of the patients undergoing complete (R0) gastric resections was 60% in the sLex high-expression group, which was significantly lower than that of the sLex low-expression group (81%) and of the no-expression group (87%) (

p < 0.05). These results suggest that high-level sLe x expression is related to both an increased risk of metastasis and poor prognosis in gastric cancer patients.

Keywords

Lymph Node Gastric Cancer Primary Tumor Lymph Node Metastasis Histologic Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© 1997 by the Société Internationale de Chir ugie

Authors and Affiliations

  • Hideki Ura
    • 1
  • Ryuichi Denno
    • 1
  • Koichi Hirata
    • 1
  • Koji Yamaguchi
    • 1
  • Takahiro Yasoshima
    • 1
  • Takayuki Shishido
    • 1
  1. 1.First Department of Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo 060, JapanJP

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