World Journal of Surgery

, Volume 20, Issue 4, pp 418–421

MODS/SIRS: Result of an Overwhelming Inflammatory Response?

  • R.J.A. Goris

DOI: 10.1007/s002689900066

Cite this article as:
Goris, R. World J. Surg. (1996) 20: 418. doi:10.1007/s002689900066

Abstract. Multiple organ dysfunction syndrome and the systemic inflammatory response syndrome are expressions of an inappropriate, generalized inflammatory response to severe inflammatory stimuli, which may be bacterial or nonbacterial in nature. The clinical signs and symptoms, morphologic alterations, and changes in oxygen transport seem to be the direct effect of phagocyte activation. So far, identifying the microorganisms and neutralizing their toxins has not been helpful in improving prognosis. As an essential adjunct to treating the bacterial or nonbacterial causes, finding safe ways of modulating the phagocyte response should be considered.

Copyright information

© 1996 by the Société Internationale de Chir ugie

Authors and Affiliations

  • R.J.A. Goris
    • 1
  1. 1.Department of Surgery, University Hospital Nijmegen, 6500 HB Nijmegen, The NetherlandsNL

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