World Journal of Surgery

, Volume 24, Issue 8, pp 990–994 | Cite as

Effect of Ischemia/Reperfusion as a Systemic Phenomenon on Anastomotic Healing in the Left Colon

  • Mehmet Ayhan Kuzu
  • Adil Tanık
  • İIlhami Taner Kale
  • Ahmet Keşşaf Aşlar
  • Cüneyt Köksoy
  • Cem Terzi
Article

Abstract

Intestinal ischemia/reperfusion provokes a local inflammatory response leading to a systemic inflammatory state. In this study we aimed to assess the effects of intestinal ischemia/reperfusion injury on anastomotic healing in the left colon with an intact vascular supply. A total of 94 Wistar albino rats were divided into three groups: sham-operated control (group I, n= 25), 30 minutes of intestinal ischemia/reperfusion (group II, n= 40), and 7-day allopurinol pretreatment and intestinal ischemia/reperfusion (group III, n= 29). After the reperfusion experiment, a segmental left colon resection and anastomosis were done. On postoperative days 3 and 7 anastomotic bursting pressure, anastomotic and operative complications, and intraabdominal adhesions were assessed. Mortality rates were 1/25, 16/40, and 4/29 for groups I, II, and III, respectively (p= 0.001). There was no difference among the groups for wound and anastomotic healing parameters evaluated by macroscopic criteria. On postoperative day 7 the mean bursting pressures were 220.3 ± 18.5, 162.0 ± 21.0, and 213.9 ± 24.7 for groups I, II, and II, respectively (p= 0.000). Significantly dense adhesions were found in group II (p= 0.000). Allopurinol pretreatment prevented the effects of ischemia/reperfusion on anastomotic healing of the left colon. Intestinal/ischemia reperfusion causes impairment of anastomotic healing of the left colon. In addition to remote organ effects, reperfusion injury may affect anastomotic healing in the viscera with an intact vascular supply.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Société Internationale de Chirurgie 2000

Authors and Affiliations

  • Mehmet Ayhan Kuzu
    • 1
  • Adil Tanık
    • 2
  • İIlhami Taner Kale
    • 2
  • Ahmet Keşşaf Aşlar
    • 2
  • Cüneyt Köksoy
    • 1
  • Cem Terzi
    • 2
  1. 1.Department of Surgery, Faculty of Medicine, University of Ankara, Sihhiye, 06100 Ankara, TurkeyTR
  2. 2.Department of Surgery, Ankara Numune Hospital, Talatpaşa Bulvari, Samanpazari, 06100 Ankara, TurkeyTR

Personalised recommendations