Hypercoagulability After Resection of Thoracic Malignancy: A Prospective Evaluation
- 52 Downloads
Rates of venous thromboembolism are increased in thoracic malignancy; however, coagulation patterns are not established. We hypothesize that patients with esophageal and lung malignancy have similar hypercoagulable pre- and postoperative profiles as defined by rotational thromboelastometry (ROTEM).
Prospective study was conducted in 47 patients with esophageal and lung cancer undergoing surgical resection. ROTEM evaluated pre/postoperative coagulation status.
Patients with thoracic malignancy were hypercoagulable by ROTEM, but not by conventional coagulation tests. Preoperative hypercoagulability was higher in lung versus esophageal cancer (64 vs. 16%, p = 0.001). Lung cancer patients that were hypercoagulable preoperatively demonstrated decreased maximum clot firmness (MCF) (p = 0.044) and increased clot time (p = 0.049) after surgical resection, suggesting reversal of hypercoagulability. Resection of esophageal cancer increased hypercoagulability (16 vs. 56%, p = 0.002) via elevated MCF (reflecting platelet activity). Hypercoagulability remained at follow-up clinic for both lung and esophageal cancer patients.
Hypercoagulability in patients with lung malignancies reversed following complete surgical resection, whereas hypercoagulability occurred only postoperatively in those with esophageal malignancies. In both, hypercoagulability was associated with fibrin and platelet function.
This study was partially supported by Grants #N140610670 from the Office of Naval Research and W81XWH1120098 from US Army Medical Research and Material Command.
Compliance with ethical standards
Conflict of interest
No conflicts of interest to declare.
Institutional review board approval and informed consented was established.
- 2.Hachey KJ, Hewes PD, Porter LP et al (2016) Caprini venous thromboembolism risk assessment permits selection for postdischarge prophylactic anticoagulation in patients with resectable lung cancer. J Thorac Cardiovasc Surg 151(37–44):e31Google Scholar
- 4.U.S. Department of Health and Human Services (2008) Surgeon General’s call to action to prevent deep vein thrombosis and pulmonary embolism. http://www.ncbi.nlm.nih.gov/books/NBK44178/. Accessed 22 June 2019.
- 40.Craig J, Aguiar–Ibanez R, Bhattacharya S (2008) The clinical and cost effectiveness of thromboelastography/thromboelastometry. HTA Programme: Health Technology Assessment Report 11. NHS Quality Improvement ScotlandGoogle Scholar