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World Journal of Surgery

, Volume 43, Issue 12, pp 3232–3238 | Cite as

Hypercoagulability After Resection of Thoracic Malignancy: A Prospective Evaluation

  • Michelle B. Mulder
  • Kenneth G. Proctor
  • Evan J. Valle
  • Alan S. Livingstone
  • Dao M. Nguyen
  • Robert M. Van HarenEmail author
Original Scientific Report
  • 52 Downloads

Abstract

Background

Rates of venous thromboembolism are increased in thoracic malignancy; however, coagulation patterns are not established. We hypothesize that patients with esophageal and lung malignancy have similar hypercoagulable pre- and postoperative profiles as defined by rotational thromboelastometry (ROTEM).

Methods

Prospective study was conducted in 47 patients with esophageal and lung cancer undergoing surgical resection. ROTEM evaluated pre/postoperative coagulation status.

Results

Patients with thoracic malignancy were hypercoagulable by ROTEM, but not by conventional coagulation tests. Preoperative hypercoagulability was higher in lung versus esophageal cancer (64 vs. 16%, p = 0.001). Lung cancer patients that were hypercoagulable preoperatively demonstrated decreased maximum clot firmness (MCF) (p = 0.044) and increased clot time (p = 0.049) after surgical resection, suggesting reversal of hypercoagulability. Resection of esophageal cancer increased hypercoagulability (16 vs. 56%, p = 0.002) via elevated MCF (reflecting platelet activity). Hypercoagulability remained at follow-up clinic for both lung and esophageal cancer patients.

Conclusions

Hypercoagulability in patients with lung malignancies reversed following complete surgical resection, whereas hypercoagulability occurred only postoperatively in those with esophageal malignancies. In both, hypercoagulability was associated with fibrin and platelet function.

Notes

Acknowledgements

This study was partially supported by Grants #N140610670 from the Office of Naval Research and W81XWH1120098 from US Army Medical Research and Material Command.

Compliance with ethical standards

Conflict of interest

No conflicts of interest to declare.

Informed consent

Institutional review board approval and informed consented was established.

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Copyright information

© Société Internationale de Chirurgie 2019

Authors and Affiliations

  • Michelle B. Mulder
    • 1
  • Kenneth G. Proctor
    • 1
  • Evan J. Valle
    • 1
  • Alan S. Livingstone
    • 1
  • Dao M. Nguyen
    • 1
  • Robert M. Van Haren
    • 2
    Email author
  1. 1.Dewitt-Daughtry Family Department of Surgery, Miller School of Medicine and Ryder Trauma CenterUniversity of MiamiMiamiUSA
  2. 2.Division of Thoracic Surgery, Department of SurgeryUniversity of Cincinnati College of MedicineCincinnatiUSA

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