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Impact of Tumor Location on Postoperative Outcome of Intraductal Papillary Neoplasm of the Bile Duct

  • Takatsugu MatsumotoEmail author
  • Keiichi Kubota
  • Hiroyuki Hachiya
  • Yuhki Sakuraoka
  • Takayuki Shiraki
  • Takayuki Shimizu
  • Shozo Mori
  • Yukihiro Iso
  • Masato Kato
  • Hidetsugu Yamagishi
  • Yasuo Imai
  • Taku Aoki
Original Scientific Report
  • 29 Downloads

Abstract

Background

The concept of intraductal papillary neoplasm of the bile duct (IPNB) has been proposed to be the biliary equivalent of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. While the classification of IPMNs is based on their location of duct involvement, such classification has not been fully evaluated for IPNBs. The aim of this study is to investigate the value of IPNB classification based on its location.

Methods

A total of 306 consecutive patients who underwent surgical resection with a diagnosis of bile duct tumor were enrolled. Among these patients, 21 were diagnosed as having IPNB. The IPNBs were classified into two groups as follows: extrahepatic IPNB, which located in the distal or perihilar bile duct, and intrahepatic IPNB, which located more peripherally than the hilar bile duct. The clinicopathological features of the two groups were then compared.

Results

Extrahepatic IPNB tended to show more invasive characteristics than intrahepatic IPNB (presence of invasive component: 40.0 vs. 9.1%, p = 0.084). Moreover, patients with extrahepatic IPNB showed significantly poorer relapse-free survival (RFS) than those with intrahepatic IPNB [5-year RFS rate (%): 81.8 vs. 16.2, p = 0.014].

Conclusion

Patients with intrahepatic IPNB show more favorable pathological characteristics and postoperative survival outcomes than those with extrahepatic IPNB.

Abbreviations

Alb

Albumin

ALP

Alkaline phosphatase

ALT

Alanine aminotransferase

AST

Aspartate aminotransferase

CA19-9

Carbohydrate antigen 19-9

CEA

Carcinoembryonic antigen

CRP

C-reactive protein

γ-GTP

Gamma-glutamyltransferase

IPMN-P

Intraductal papillary mucinous neoplasm of the pancreas

IPNB

Intraductal papillary neoplasm of the bile duct

PLT

Platelet

TP

Total protein

WHO

World Health Organization

Notes

Compliance with ethical standards

Conflict of interest

We have no conflicts of interest to declare.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Société Internationale de Chirurgie 2019

Authors and Affiliations

  • Takatsugu Matsumoto
    • 1
    Email author
  • Keiichi Kubota
    • 1
  • Hiroyuki Hachiya
    • 1
  • Yuhki Sakuraoka
    • 1
  • Takayuki Shiraki
    • 1
  • Takayuki Shimizu
    • 1
  • Shozo Mori
    • 1
  • Yukihiro Iso
    • 1
  • Masato Kato
    • 1
  • Hidetsugu Yamagishi
    • 2
  • Yasuo Imai
    • 2
  • Taku Aoki
    • 1
  1. 1.Department of Gastroenterological SurgeryDokkyo Medical UniversityMibuJapan
  2. 2.Department of Diagnostic PathologyDokkyo Medical University HospitalMibuJapan

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