World Journal of Surgery

, Volume 43, Issue 2, pp 552–558 | Cite as

Results of Duodenopancreatic Reoperations in Multiple Endocrine Neoplasia Type 1

  • Max B. AlbersEmail author
  • Jerena Manoharan
  • Carmen Bollmann
  • Maximilian P. Chlosta
  • Katharina Holzer
  • Detlef K. Bartsch
Original Scientific Report (including Papers Presented at Surgical Conferences)



To evaluate the outcome of duodenopancreatic reoperations in patients with multiple endocrine neoplasia type 1 (MEN1).


MEN1 patients who underwent reoperations for duodenopancreatic neuroendocrine neoplasms (dpNENs) were retrieved from a prospective database and retrospectively analyzed.


Twelve of 101 MEN1 patients underwent up to three reoperations, resulting in a total of 18 reoperations for dpNEN recurrence. Patients initially underwent either formal pancreatic resections (n = 7), enucleations (n = 3), or duodenotomy with lymphadenectomy for either NF-pNEN (seven patients), Zollinger–Ellison syndrome (ZES, three patients), organic hyperinsulinism (one patient) or VIPoma (one patient). Six patients had malignant dpNENs with lymph node (n = 5) and/or liver metastases (n = 2). The indication of reoperations was NF-pNEN (five patients), ZES (five patients), organic hyperinsulinism (one patient), and recurrent VIPoma (one patient). Median time to first reoperation was 67.5 (range 6–251) months. Five patients required a second duodenopancreatic reoperation for 60–384 months after initial surgery, and one patient underwent a third reoperation after 249 months. The rate of complications (Clavien–Dindo ≥3) was 28%. Four patients required completion pancreatectomy. Six patients developed pancreoprivic diabetes. After a median follow-up of 18 (6–34) years after initial surgery, ten of 12 patients are alive, one died of metastatic pancreatic VIPoma, and one died of metastatic thymic NEN.


Reoperations are frequently necessary for dpNEN in MEN1 patients, but are not associated with an increased perioperative morbidity in specialized centers. Organ-sparing resections should be preferred as initial duodenopancreatic procedures to maintain pancreatic function and avoid completion pancreatectomy.



We thank all MEN1 patients participating in our controlled screening program.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Société Internationale de Chirurgie 2018

Authors and Affiliations

  • Max B. Albers
    • 1
    Email author
  • Jerena Manoharan
    • 1
  • Carmen Bollmann
    • 1
  • Maximilian P. Chlosta
    • 1
  • Katharina Holzer
    • 1
  • Detlef K. Bartsch
    • 1
  1. 1.Department of Visceral-, Thoracic- and Vascular SurgeryPhilipps University of MarburgMarburgGermany

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