World Journal of Surgery

, Volume 42, Issue 8, pp 2469–2475 | Cite as

Adrenal Ganglioneuroma: Features and Outcomes of 42 Cases in a Chinese Population

  • Jing Xie
  • Jun Dai
  • Wen-long Zhou
  • Fu-kang Sun
Original Scientific Report



Adrenal ganglioneuromas (AGNs) are extremely rare benign neoplasms. This study is to share our experience regarding diagnostic and operative management of these tumors.


Clinical details as well as follow-up data were retrospectively analyzed in 42 primary AGN patients who received operative resection at a tertiary referral hospital in China between May 2005 and July 2016.


The mean age of the patients at diagnosis was 35.3 years (range 13–59 years). Among the patients, 28 were asymptomatic. The mean preoperative size was 5.3 ± 2.2 cm (range 2.1–14.0 cm), and 17 cases were larger than 5 cm. All patients underwent operative resection as open adrenalectomy in 20 patients and laparoscopy in 22 patients. The mean tumor size on pathologic examination was 6.0 ± 2.6 cm (range 2.2–17.0 cm). Laparoscopic operation showed its advantages over open surgery on the postoperative duration (5.0 vs. 7.3 days, p < 0.001) and estimated blood loss (69.5 vs. 157.5 ml, p = 0.047). No patient had recurrence or metastasis during a median follow-up of 70.5 months (range 3.7–164.3 months).


We describe the largest AGN series reported to date. The preoperative diagnosis of AGN remains difficult despite of the progression of imaging examination. After complete resection, the prognosis of AGN patients is excellent. Laparoscopic approach has its advantages in the resection of AGNs.



This study was supported by funding from National Natural Science Foundation of China (No. 81572621).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Société Internationale de Chirurgie 2018

Authors and Affiliations

  1. 1.Department of Urology, Shanghai Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

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