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Percutaneous Microwave Ablation of Metastatic Lymph Nodes from Papillary Thyroid Carcinoma: Preliminary Results

  • Wei Zhou
  • Yudong Chen
  • Lu Zhang
  • Xiaofeng Ni
  • Shangyan Xu
  • Weiwei Zhan
Original Scientific Report
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Abstract

Background

Our purpose is to assess the effectiveness and safety of ultrasound-guided percutaneous microwave ablation (MWA) for lymph node metastases (LNMs) from papillary thyroid carcinomas (PTC).

Methods

In total, 14 patients with recurrent PTC were enrolled in this retrospective study. The vascularity within the ablation zone was evaluated by contrast-enhanced ultrasonography (CEUS) after MWA. Patients were followed up with measurement of the size and volume of tumor, serum thyroglobulin, and clinical evaluation at 7 days, 1, 3, 6 months, and every 6 months thereafter.

Results

Twenty-one LNMs were confirmed by biopsy and successfully treated by MWA in a single session. No incomplete ablation was detected by CEUS after treatment. The average largest diameter and volume of the tumors were reduced from 10.1 ± 4.7 mm (range, 3.1–20.0 mm) and 291.9 ± 255.6 mm3 (range, 11.6–766.6 mm3) to 0.9 ± 1.6 mm (range, 0–4.1 mm; p < 0.05) and 4.0 ± 9.0 mm3 (range, 0–31.6 mm3; p < 0.05) at the final follow-up. Neither progression of treated tumors nor newly suspicious LNMs could be detected after treatment. The overall complication rate was 7.1% (1/14).

Conclusions

Ultrasound-guided MWA can effectively control LNMs from PTC, but it is less safe for tumors in the central compartment. MWA may become an alternative therapy in selected PTC patients, who were ineligible or refused to undergo repeated neck explorations.

Abbreviations

LNMs

Lymph node metastases

PTC

Papillary thyroid carcinoma

US

Ultrasound

CEUS

Contrast-enhanced ultrasonography

MWA

Microwave ablation

FNAB

Fine-needle aspiration biopsy

Notes

Acknowledgement

This work was supported by Grants from the Capacity building project of auxiliary department (Ultrasonic Medicine), clinical science and technology innovation project from Shanghai Shen Kang Hospital Development Center (No. SHDC22015006).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Société Internationale de Chirurgie 2018

Authors and Affiliations

  • Wei Zhou
    • 1
  • Yudong Chen
    • 1
  • Lu Zhang
    • 1
  • Xiaofeng Ni
    • 1
  • Shangyan Xu
    • 1
  • Weiwei Zhan
    • 1
  1. 1.Department of Ultrasound, Rui Jin Hospital, School of MedicineShanghai Jiao Tong UniversityShanghaiChina

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