Is Routine Intraoperative Contrast-Enhanced Ultrasonography Useful During Whole Liver Transplantation?
- 55 Downloads
Vascular complications following liver transplantation (LT) may result from technical deficiencies. Intraoperative diagnosis remains challenging but can prevent serious delayed complications. Intraoperative Doppler ultrasonography (IOUS) represents the gold standard for imaging, although it requires radiological skills. Contrast-enhanced ultrasonography has been reported during postoperative assessments, but never intraoperatively (CE-IOUS). The aim of this study was to assess the feasibility of routine CE-IOUS, to evaluate its impact on surgical strategy and its usefulness.
All 553 whole LTs performed in our tertiary centre between 01/2010 and 12/2014 were reviewed. We compared perioperative outcomes and long-term survival in IOUS (n = 370) versus CE-IOUS (n = 103) groups. Secondarily, the seven cases where the two imaging findings conflicted (CE+ Group) were matched 1:2 and compared with an exclusively IOUS procedure (CE− Group, n = 14) to assess the consequences of a specific CE-guided strategy.
CE-IOUS assessments were successful in 100% of cases, without any adverse effects. Vascular complications and patient/graft survival rates were identical in the IOUS and CE-IOUS groups (p = 0.65, 0.95 and 0.86, respectively). CE-IOUS confirmed IOUS findings in 93% of cases (n = 96) and led to the realization of an additional procedure (median arcuate ligament lysis) and six conservative strategies despite poor arterial (n = 5) or venous flow (n = 1) under Doppler analysis. The CE+ and CE− groups presented statistically identical perioperative and long-term outcomes.
This study demonstrated the feasibility of CE-IOUS during whole LT. However, we failed to demonstrate any advantages of CE-IOUS over IOUS. Therefore, IOUS currently remains the gold-standard imaging technique for the intraoperative assessment of vascular patency.
Intraoperative contrast-enhanced ultrasonography
Comprehensive Complication Index
Common hepatic artery
Hepatic artery stenosis
Hepatic artery thrombosis
Intensive care unit
Intraoperative Doppler ultrasonography
Portal vein thrombosis
Compliance with ethical standards
Conflict of interest
The authors declare no conflicts of interest.
All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors. Informed consent was obtained from all individual participants included in the study.
- 7.Hwang HJ, Kim KW, Jeong WK, Kim SY, Song G-W, Hwang S et al (2009) Hepatic outflow obstruction at middle hepatic vein tributaries or inferior right hepatic veins after living donor liver transplantation with modified right lobe graft: comparison of CT and Doppler ultrasound. Am J Roentgenol 193(3):745–751CrossRefGoogle Scholar
- 9.Claudon M, Dietrich CF, Choi BI, Cosgrove DO, Kudo M, Nolsøe CP et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver–update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultraschall Med 34(1):11–29PubMedGoogle Scholar
- 17.García-Criado Á, Gilabert R, Bianchi L, Vilana R, Burrel M, Barrufet M et al (2015) Impact of contrast-enhanced ultrasound in the study of hepatic artery hypoperfusion shortly after liver transplantation: contribution to the diagnosis of artery steal syndrome. Eur Radiol 25(1):196–202CrossRefPubMedGoogle Scholar
- 36.Zheng R-Q, Mao R, Ren J, Xu E-J, Liao M, Wang P et al (2010) Contrast-enhanced ultrasound for the evaluation of hepatic artery stenosis after liver transplantation: potential role in changing the clinical algorithm. Liver Transplant 16(6):729–735Google Scholar
- 37.Park YS, Kim KW, Lee SJ, Lee J, Jung D-H, Song G-W et al (2011) Hepatic arterial stenosis assessed with doppler US after liver transplantation: frequent false-positive diagnoses with tardus parvus waveform and value of adding optimal peak systolic velocity cutoff. Radiology 260(3):884–891CrossRefPubMedGoogle Scholar