Impact of Drain Insertion After Perforated Peptic Ulcer Repair in a Japanese Nationwide Database Analysis
Many perforated peptic ulcers (PPUs) require surgical repair due to diffuse peritonitis. However, few studies have examined the clinical effects of postoperative drainage after PPU repair. This study aimed to investigate the drain insertion rates in patients who underwent PPU repair in Japan, and to clarify the impact of drain insertion on the postoperative clinical course.
A retrospective nationwide cohort study was performed using administrative claims data of patients who had undergone PPU repair between 2010 and 2016. These patients were divided into two groups based on whether or not they had received a postoperative abdominal drain. Using propensity score matching, we compared the incidences of postoperative interventions for abdominal complications between both groups.
A total of 4869 patients from 324 hospitals were analyzed. At the hospital level, drains were placed in all PPU repair patients in 229 (70.7%) hospitals. At the patient level, 4401 patients (90.4%) had drains inserted. The drain group was associated with a higher emergency admission rate, poorer preoperative shock status, longer anesthetic time, and a higher amount of intra-abdominal irrigation. In the propensity score-matched patients, the drain group had a significantly lower incidence of postoperative interventions than the no-drain group (1.9 vs. 5.6%; risk ratio = 0.35; 95% confidence interval 0.16–0.73; P = 0.003).
Postoperative drainage was performed in the majority of patients who underwent PPU repair in Japan. Drainage following PPU repair may facilitate patient recovery by reducing the need for postoperative interventions.
QIP data operations were supported by a Health Sciences Research Grant from the Ministry of Health, Labour and Welfare of Japan (Grant No. H27-iryo-ippan-001) and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (No. 16H02634). The funding sources had no role in the study design, data collection, analysis, interpretation of the data, or the decision to submit the manuscript for publication.
KO contributed to the study conception and design, data collection, analysis, interpretation of the results, drafting of the manuscript, and critical review for important intellectual content. KH andTN contributed to the study design, analysis, interpretation of the results, and critical review for important intellectual content. SK contributed to the study design, data collection, analysis, interpretation of the results, and critical review for important intellectual content. HH and YS contributed to the study design, interpretation of the results, and critical review for important intellectual content. YI contributed to the study design, data acquisition, interpretation of the results, and critical review for important intellectual content. All authors read and approved the final version of the manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 9.Kojika M, Sato N, Yaegashi Y et al (2009) Should a drain be inserted during surgery for peritonitis? J Abdom Emerg Med 29:827–834 (in Japanese) Google Scholar