World Journal of Surgery

, Volume 41, Issue 5, pp 1259–1266 | Cite as

Metalloproteinases and Their Inhibitors in Patients with Inguinal Hernia

  • Arda IsikEmail author
  • Cebrail Gursul
  • Kemal Peker
  • Merve Aydın
  • Deniz Fırat
  • İsmayil Yılmaz
Original Scientific Report



The aim of this prospective study is to investigate if there is a relationship between inguinal hernia, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs).

Materials and methods

This case control study was performed on patients admitted to the general surgery department of Erzincan University Hospital. Four groups were created: control, indirect hernia, direct hernia, and bilateral hernia. All groups were comprised of 11 patients. Serum and tissue levels of MMP-1, MMP-2, MMP-9, MMP-13, TIMP-1, TIMP-2, TIMP-3, and hydroxyproline were evaluated.


MMPs values were significantly high at hernia groups, especially at bilateral hernia group (p < 0.05), whereas TIMPs values were significantly low at bilateral hernia group (p < 0.05). MMPs values were increasing at hernia groups in an order as control, indirect, direct, and bilateral. TIMPs values were decreasing at hernia groups in an order as control, indirect, direct, and bilateral.


Increased levels of MMP-1-2-9-13 and decreased levels of TIMP-1-2-3 may have played role in the formation of inguinal hernia. Hernia is not only a local defect, but a reflection of systemic disease. This is even more significant for bilateral hernias.


Inguinal Hernia Abdominal Aortic Aneurysm Incisional Hernia Abdominal Aortic Aneurysm Varicocele 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study is funded by the Scientific Research Projects Unit of Erzincan University, Erzincan, Turkey.

Compliance with ethical standards

Conflict of interest

AI, CG, KP, MA, DF, IY declare no conflict of interest.


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Copyright information

© Société Internationale de Chirurgie 2016

Authors and Affiliations

  • Arda Isik
    • 1
    Email author
  • Cebrail Gursul
    • 2
  • Kemal Peker
    • 1
  • Merve Aydın
    • 3
  • Deniz Fırat
    • 1
  • İsmayil Yılmaz
    • 1
  1. 1.Department of General Surgery, School of MedicineErzincan UniversityErzincanTurkey
  2. 2.Department of Physiology, School of MedicineErzincan UniversityErzincanTurkey
  3. 3.Department of Medical Microbiology, School of MedicineErzincan UniversityErzincanTurkey

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