World Journal of Surgery

, Volume 40, Issue 12, pp 2970–2975 | Cite as

Clinicopathological Features of Ganglioneuroma Originating From the Adrenal Glands

  • Joon-Hyop Lee
  • Young Jun Chai
  • Tae-Hyung Kim
  • June Young Choi
  • Kyu Eun LeeEmail author
  • Hyun-Young Kim
  • Yoo-Seok Yoon
  • Hyeon Hoe Kim
Original Scientific Report



Ganglioneuromas are benign tumors that rarely develop from adrenal glands. In this study, we present our clinical experience of patients with adrenal ganglioneuroma (AGN).


Demographic, diagnostic, surgical, and pathologic findings of patients who were adrenalectomized as a result of AGN were retrospectively reviewed from the database of a tertiary referral hospital.


Among 1784 patients who underwent an adrenalectomy between 2002 and 2015, 35 (1.9 %; 14 males, 21 females) were diagnosed with AGN. Mean age was 33.4 ± 18.7 years (0–84). Twenty-nine (82.9 %) were asymptomatic, four (11.4 %) complained of abdominal discomfort, and two (5.7 %) had abdominal distension. Preoperative computed tomography (CT) reported AGN in 22 (62.9 %) cases. Precontrast Hounsfield units, increased postcontrast phase attenuation, and well-defined borders were characteristic CT features of AGN. Mean tumor size was 6.3 ± 3.3 cm (range, 1.5–16.0). No recurrence occurred during a median follow-up period of 19 months (range, 1–120).


AGN was asymptomatic in most cases and diagnosis may be challenging. Adrenalectomy is a safe treatment modality for AGN and ensures favorable outcomes when diagnosed.


Early Gastric Cancer Hounsfield Unit Laparoscopic Adrenalectomy Adrenal Adenoma Compute Tomography Feature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We wish to thank Dr. Jiwon Koh from the Department of Pathology, Seoul National University Hospital and College of Medicine for her contribution in reviewing and confirming common microscopic AGN features in the surgical slides.

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest or financial ties to disclose.


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Copyright information

© Société Internationale de Chirurgie 2016

Authors and Affiliations

  • Joon-Hyop Lee
    • 1
  • Young Jun Chai
    • 2
    • 3
  • Tae-Hyung Kim
    • 4
  • June Young Choi
    • 1
  • Kyu Eun Lee
    • 2
    • 5
    Email author
  • Hyun-Young Kim
    • 6
  • Yoo-Seok Yoon
    • 1
  • Hyeon Hoe Kim
    • 7
  1. 1.Department of SurgerySeoul National University Bundang HospitalGyeonggi-doKorea
  2. 2.Cancer Research InstituteSeoul National University College of MedicineSeoulKorea
  3. 3.Department of SurgerySeoul National University Boramae Medical CenterSeoulKorea
  4. 4.Department of RadiologySeoul National University Hospital and College of MedicineSeoulKorea
  5. 5.Department of SurgerySeoul National University Hospital and College of MedicineSeoulKorea
  6. 6.Department of Pediatric SurgerySeoul National University Children’s HospitalSeoulKorea
  7. 7.Department of UrologySeoul National University Hospital and College of MedicineSeoulKorea

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