World Journal of Surgery

, Volume 40, Issue 9, pp 2139–2143 | Cite as

Multifocal Versus Solitary Papillary Thyroid Carcinoma

  • Andreas Kiriakopoulos
  • Athanassios Petralias
  • Dimitrios Linos
Original Scientific Report



Papillary Thyroid Carcinoma (PTC) which accounts for >85 % of all thyroid cancers in iodine-rich areas, appears either as a single tumor or as two or more, neoplastic foci within the thyroid gland (Multifocal PTC). We present the comparative results between solitary and MFC PTC.

Materials and methods

Demographics, tumor characteristics (size, laterality, foci number, histologic subtype) and TNM staging were compared between solitary and MFPTC patients. The presence of lymphocytic or Hashimoto’s thyroditis was also recorded.


From January 2008 to December 2012, among 647 PTC patients, 241(37.2 %) had MFPTC 177 females (73.4 %) and 64 males (26.6 %), mean age 48.5 years (range 12–87). Mean number of tumor foci was 3.3 (range 2–26). MFPTC patients presented with more advanced T stage (28.2 vs. 18.7 %, p = 0.01) and more LN metastases (28.6 vs. 15.5 %, p < 0.001). Foci number correlates with male gender and LN metastases (p = 0.014 and p = 0.019, respectively). Central (N1a) or lateral (N1b) LN involvement correlates strongly with male gender (p  = 0.024) and younger age (p < 0.001). The follicular variant was the next most frequent histologic subtype associated with extremely rare LN metastases.


MFPTC comprises a more aggressive form of papillary thyroid cancer since it is associated with more frequent N1a/ N1b disease and occurs more frequently in T3/T4 patients. MFPTC foci number correlates with male gender and LN metastases.


Papillary Thyroid Carcinoma Papillary Thyroid Cancer Lateral Lymph Node Follicular Variant Papillary Thyroid Carcinoma Patient 
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Copyright information

© Société Internationale de Chirurgie 2016

Authors and Affiliations

  • Andreas Kiriakopoulos
    • 1
  • Athanassios Petralias
    • 2
  • Dimitrios Linos
    • 1
    • 3
  1. 1.Department of Surgery, 1st Surgical ClinicHygeia HospitalAthensGreece
  2. 2.Institute of Preventive Medicine, Environmental & Occupational Health - ProlepsisAthensGreece
  3. 3.Medical SchoolNational and Kapodestrian University of AthensAthensGreece

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