World Journal of Surgery

, Volume 40, Issue 2, pp 315–322 | Cite as

Optimising Breast Conservation Treatment for Multifocal and Multicentric Breast Cancer: A Worthwhile Endeavour?

  • Mona P. TanEmail author
  • Nadya Y. Sitoh
  • Yih Yiow Sitoh
Original Scientific Report



Breast conservation treatment (BCT) is an accepted treatment modality for early breast cancer. However, multifocal and multicentric breast cancer (MFMCBC) is a relative contraindication to BCT. This study was performed to compare BCT rates in MFMCBC and unifocal tumours and its outcomes.


A retrospective analysis was performed for patients with breast malignancies who underwent operative treatment between 2009 and 2011. Successful BCT was defined as the ability to obtain clear margins for all tumour foci through a single incision with acceptable resultant cosmesis.


A total of 160 patients were analysed, of which 40 were MFMCBC. Thirty-four of the 40 patients with MFMCBC underwent BCT (85 %). After a mean follow-up period of 55 months, there were no local recurrences in patients with MFMCBC.


BCT was achieved in 85 % of the patients with MFMCBC in this cohort without evidence of poorer local control. Further investigation is needed to confirm this finding for its potential contribution to improved survival outcomes.


Single Incision Breast Conservation Therapy Mastectomy Rate Breast Conservation Therapy Unifocal Tumour 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Société Internationale de Chirurgie 2015

Authors and Affiliations

  • Mona P. Tan
    • 1
    Email author
  • Nadya Y. Sitoh
    • 2
  • Yih Yiow Sitoh
    • 2
  1. 1.Breast SurgeryMammoCareSingaporeSingapore
  2. 2.Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

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