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World Journal of Surgery

, Volume 40, Issue 4, pp 982–986 | Cite as

The Characteristics of Bone Metastasis in Patients with Colorectal Cancer: A Long-Term Report from a Single Institution

  • Se-Jin BaekEmail author
  • Hyuk Hur
  • Byung-Soh Min
  • Seung-Hyuk Baik
  • Kang-Young Lee
  • Nam-Kyu Kim
Original Scientific Report

Abstract

Background

Bone metastasis in patients with colorectal cancer (CRC) is very rare, and data are extremely lacking. We aimed to evaluate the characteristics of bone metastasis in patients with CRC.

Materials and methods

We performed a chart review of 63 patients (1.1 %) with bone metastasis among 5479 patients who underwent surgery for CRC.

Results

Most patients were stage 3 (17.5 %) or 4 (73.0 %), and 32 patients (50.8 %) were diagnosed with bone metastasis at initial diagnoses of CRC. Thirty-one patients developed bone metastasis during the follow-up period with median 10.1-month interval. PET–CT was most frequently used for the diagnosis of bone metastasis (71.4 %), and the spine was the most commonly involved site (77.8 %). Most patients had multiple bone metastases (73.0 %) and other metastases (87.3 %). Bone pain was the most common skeletal-related event (25.4 %), and patients were treated with radiation (25.4 %), surgery (14.3 %), or bisphosphonate (6.3 %). The median survival time was 17.8 months, and the 5-year survival rate was 5.7 %. In the multivariate analysis, the risk factors for survival included initial bone metastasis (hazard ratio [HR] 3.03; P < 0.001) and bone metastasis from colon cancer (HR 1.87; P = 0.04).

Conclusion

Bone metastasis in patients with CRC is extremely rare and shows poor prognosis.

Keywords

Colorectal Cancer Bone Metastasis Zoledronic Acid Bone Pain Pamidronate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Author contributions

Baek SJ acquired, analyzed, and interpreted the data and constructed the manuscript; Kim NK conceptualized this paper; Hur H, Min BS, Baik SH, and Lee KY reviewed the manuscript.

Compliance with ethical standards

Disclosure

The authors have no source of support in the form of equipment, drugs, or grants to declare.

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Copyright information

© Société Internationale de Chirurgie 2015

Authors and Affiliations

  • Se-Jin Baek
    • 1
    Email author
  • Hyuk Hur
    • 1
  • Byung-Soh Min
    • 1
  • Seung-Hyuk Baik
    • 1
  • Kang-Young Lee
    • 1
  • Nam-Kyu Kim
    • 1
  1. 1.Division of Colon and Rectal Surgery, Department of SurgeryYonsei University College of MedicineSeoulSouth Korea

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