World Journal of Surgery

, Volume 38, Issue 9, pp 2395–2402 | Cite as

Antiviral Therapy Decreases Recurrence of Hepatitis B Virus-related Hepatocellular Carcinoma after Curative Resection: A Meta-analysis

  • Yanming Zhou
  • Zhansai Zhang
  • Yanfang Zhao
  • Lupeng Wu
  • Bin Li



The long-term outcome after curative resection of hepatocellular carcinoma (HCC) remains unsatisfactory because of the high incidence of recurrence. The present study was intended to assess the impact of hepatitis B virus (HBV) DNA level and nucleos(t)ide analog therapy on posthepatectomy recurrence of HBV-related HCC.


Eligible studies were identified through a computerized literature search. The pooled relative risk ratio (RR) with 95 % confidence interval (CI) was calculated using Review Manager 5.1 Software.


Twenty studies with a total of 8,204 participants were included for this meta-analysis. Pooled analysis showed that high viral load was significantly associated with risk of recurrence (RR: 1.85, 95 % CI: 1.41–2.42; P < 0.001), poorer disease-free survival (DFS) (RR: 1.96, 95 % CI: 1.62–2.38; P < 0.001), and poorer overall survival (OS) (RR: 1.47, 95 % CI: 1.22–1.77; P < 0.001) of HBV-related HCC after surgical resection. Nucleos(t)ide analog therapy significantly decreased the recurrence risk (RR: 0.69, 95 % CI: 0.59–0.80; P < 0.001) and improved both DFS (RR: 0.70, 95 % CI: 0.58–0.83; P < 0.001) and OS (RR: 0.46, 95 % CI: 0.32–0.68; P < 0.001).


High DNA level is associated with posthepatectomy recurrence of HBV-related HCC. Nucleos(t)ide analog therapy improves the prognosis of HBV-related HCC after resection.


Overall Survival Risk Ratio High Viral Load Telbivudine Poor Overall Survival 
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Copyright information

© Société Internationale de Chirurgie 2014

Authors and Affiliations

  • Yanming Zhou
    • 1
  • Zhansai Zhang
    • 2
  • Yanfang Zhao
    • 3
  • Lupeng Wu
    • 1
  • Bin Li
    • 1
  1. 1.Department of Hepatobiliary & Pancreatovascular Surgery, Oncologic Center of XiamenFirst Affiliated Hospital of Xiamen UniversityXiamenChina
  2. 2.Testing Center for Occupational HealthShanghai Institute of Occupational Safety and HealthShanghaiChina
  3. 3.Department of Health StatisticsSecond Military Medical UniversityShanghaiChina

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