World Journal of Surgery

, Volume 38, Issue 5, pp 1164–1176

Surgical Treatment of 144 Cases of Hilar Cholangiocarcinoma Without Liver-Related Mortality

  • Norihiko Furusawa
  • Akira Kobayashi
  • Takahide Yokoyama
  • Akira Shimizu
  • Hiroaki Motoyama
  • Sin-ichi Miyagawa
Article

Abstract

Background

The present study evaluated whether the short- and long-term outcomes improved during our 23 years of experience treating 144 consecutive patients with hilar cholangiocarcinoma.

Methods

Patients treated between 1990 and 2000 (period 1; n = 70) were retrospectively compared with those treated between 2001 and 2012 (period 2; n = 74). Mortality and major complications were defined as any death occurring within 90 days of surgery and a grade III–IV complication according to the Clavien classification, respectively.

Results

The mortality and major complication rates decreased from 1.2 and 34 % during period 1–0 and 24 % during period 2, respectively. Although the surgical procedure was comparable between the two periods, the median blood loss was significantly reduced from 1,020 mL during period 1–745 mL during period 2 (P = 0.003), and blood loss was the only significant predictor of postoperative morbidity in a multivariable analysis. The R0 resection rate (70 vs. 78 %, P = 0.250) and the 5-year survival rate (33 vs. 35 %, P = 0.529) were similar for the two periods. A multivariable analysis identified positive nodal involvement and R1–2 resection as independent prognostic factors for survival.

Conclusions

The perioperative outcomes after surgical treatment for hilar cholangiocarcinoma have steadily improved through the accumulation of experience and meticulous surgical techniques to reduce blood loss. Further improvement of the R0 resection rate could prolong patient survival.

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Copyright information

© Société Internationale de Chirurgie 2013

Authors and Affiliations

  • Norihiko Furusawa
    • 1
  • Akira Kobayashi
    • 1
  • Takahide Yokoyama
    • 1
  • Akira Shimizu
    • 1
  • Hiroaki Motoyama
    • 1
  • Sin-ichi Miyagawa
    • 1
  1. 1.First Department of SurgeryShinshu University School of MedicineMatsumotoJapan

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