Oncological Feasibility of Laparoscopic Distal Pancreatectomy for Adenocarcinoma: A Single-Institution Comparative Study
- 484 Downloads
Laparoscopic distal pancreatectomy (LDP) is performed increasingly for pancreatic pathology in the body and tail of the pancreas. However, only few reports have compared its oncological efficacy with open distal pancreatectomy (ODP). We compared these two techniques in patients with pancreatic ductal adenocarcinoma.
From a prospectively maintained database, all patients who underwent either LDP or ODP for adenocarcinoma in the body and tail of the pancreas between January 2008 and December 2011 were compared. Data were analysed using SPSS® v19 utilising standard tests. A p value <0.05 was considered significant.
Of 101 patients who underwent distal pancreatectomy, 22 had histologically confirmed adenocarcinoma (LDP n = 8, ODP n = 14). Both groups were well matched for age and the size of tumour (22 vs. 32 mm, p = 0.22). Intraoperative blood loss was 306 ml compared with 650 ml for ODP (p = 0.152). A longer operative time was noted for LDP (376 vs. 274 min, p < 0.05). Total length of stay was shorter for LDP compared with ODP (8 vs. 12 days, p = 0.05). The number of postoperative pancreatic fistulas were similar (LDP n = 2 vs. ODP n = 3, p = 0.5). Complete resection (R0) was achieved in 88 % of LDP (n = 7) compared with 86 % of ODP (n = 12). The median number of lymph nodes harvested was 16 for LDP versus 14 for ODP. Overall 3-year survival also was similar: LDP = 82 %, ODP = 74 % (p = 0.89).
From an oncological perspective, LDP is a viable procedure and its results are comparable to ODP for ductal adenocarcinomas arising in the body and tail of the pancreas.
KeywordsPancreatic Fistula Distal Pancreatectomy Pancreatic Ductal Adenocarcinoma Laparoscopic Distal Pancreatectomy Postoperative Pancreatic Fistula
Conflict of interest
- 17.Campbell F, Bennett M, Foulis A (2002) Minimum dataset for histopathological reporting of pancreatic, ampulla of Vater and bile duct carcinoma, 1st edn. Royal College of Pathology, LondonGoogle Scholar
- 18.Kloppel G, Lingenthal G, von Bulow M et al (1985) Histological and fine structure features of pancreatic ductal adenocarcinoma in relation to growth and prognosis: studies in xenografted tumours and clinicopathological correlation in a series of 75 case. Histopathology 9(8):841–856PubMedCrossRefGoogle Scholar
- 25.Menon K, Gomez D, Smith AM et al (2009) Impact of margin status on survival following pancreatoduodenectomy for cancer: the leeds pathology protocol (LEEP). HPB(Oxford) 11(1):18–24Google Scholar