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World Journal of Surgery

, Volume 38, Issue 2, pp 426–430 | Cite as

HER2 Expression in Carcinomas of the True Cardia (Siewert Type II Esophagogastric Junction Carcinoma)

  • Hitoshi Katai
  • Michihiro Ishida
  • Hiroharu Yamashita
  • Masaki Ohashi
  • Shinji Morita
  • Hiroshi Katayama
  • Takeo Fukagawa
  • Ryoji Kushima
Article

Abstract

Objectives

To evaluate the HER2 status in patients with Siewert type II esophagogastric junction carcinoma.

Background

Trastuzumab is now approved for use in the treatment of human epidermal growth factor receptor 2 (HER2)-positive unresectable metastatic gastric or esophagogastric junction (EGJ) carcinoma. Several studies have evaluated HER2 status in EGJ carcinoma, but none has addressed the implication of HER2 positivity in patients with Siewert type II EGJ carcinoma.

Methods

We retrospectively evaluated the frequency of HER2 positivity in a large single-center cohort of 208 patients with Siewert type II tumors. The relations between HER2 expression and the outcomes and other clinicopathologic features were examined.

Results

Overall, 18.2 % (38/208) of patients in our cohort had HER2-positive tumors. HER2 positivity was associated only with differentiated carcinomas. The 5-year overall survival (OS) rate was 58.7 %. The 5-year OS rates in the patient groups with HER2-negative and HER2-positive tumors were 61.2 and 48.5 %, respectively. There was no significant difference between the groups. Recurrence in the liver was observed in 23.7 % patients of the HER2-positive group and 7.6 % patients of the HER2-negative group. Multivariate analysis to identify the risk factors for liver recurrence revealed only HER2 positivity (p = 0.0155) as an independent predictive factor.

Conclusions

HER2 positivity is a powerful predictor of liver recurrence in patients with Siewert type II EGJ carcinoma. Use of trastuzumab in combination with chemotherapy in an adjuvant setting can be a potentially useful therapeutic strategy to prevent hepatic recurrence in patients with resectable EGJ adenocarcinoma showing HER2 overexpression.

Keywords

Overall Survival Trastuzumab Liver Recurrence Siewert Type Esophagogastric Junction Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

The authors have no conflicts of interest to declare.

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Copyright information

© Société Internationale de Chirurgie 2013

Authors and Affiliations

  • Hitoshi Katai
    • 1
  • Michihiro Ishida
    • 1
  • Hiroharu Yamashita
    • 1
  • Masaki Ohashi
    • 1
  • Shinji Morita
    • 1
  • Hiroshi Katayama
    • 1
  • Takeo Fukagawa
    • 1
  • Ryoji Kushima
    • 2
  1. 1.Gastric Surgery DivisionNational Cancer Center HospitalTokyoJapan
  2. 2.Pathology DivisionNational Cancer Center HospitalTokyoJapan

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