World Journal of Surgery

, Volume 38, Issue 1, pp 168–176 | Cite as

The Determination of Bile Leakage in Complex Hepatectomy Based on the Guidelines of the International Study Group of Liver Surgery

  • Yoshiro Taguchi
  • Tomoki Ebata
  • Yukihiro Yokoyama
  • Tsuyoshi Igami
  • Gen Sugawara
  • Toshio Kokuryo
  • Kenji Wakai
  • Masato NaginoEmail author



The International Study Group of Liver Surgery (ISGLS) has defined bile leakage as a drain fluid-to-serum total bilirubin concentration (TBC) ratio (the bilirubin ratio) ≥3.0. The aim of the present study was to determine the clinical significance of this definition, and to outline characteristics of bile leakage in complex hepatectomy.


The TBCs of the serum and drain fluid were measured on postoperative days (POD) 1, 3, and 7 in 241 patients who had undergone hepatobiliary resection. The validation of the bilirubin ratio and predictors of bile leakage were retrospectively assessed.


Grade A, B, or C bile leakage was found in 23 (9.5 %), 66 (27.4 %), and 0 patients, respectively. The median duration of drainage was 27 days in grade B bile leakage. The sensitivity and specificity of the bilirubin ratio for detecting grade B bile leakage were 59 and 87 %, respectively. The area under the receiver operating characteristics curve of the drain fluid TBC on POD 3 had the highest predictive value: 68 % sensitivity and 76 % specificity for a drain fluid TBC of 3.7 mg/dL. The multivariate analysis demonstrated that operative time, left trisectionectomy, bilirubin ratio, and TBC of the drain fluid on POD 3 were independent predictors of grade B bile leakage.


In complex hepatectomy, bile leakage develops most frequently after left trisectionectomy and often results in a refractory clinical course. The ISGLS biochemical definition is valid, and a combination of bilirubin ratio and drain fluid TBC may enhance risk prediction for grade B bile leakage.


Receiver Operating Characteristic Curve Bile Leakage Drain Fluid Bile Duct Resection Ethanol Ablation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Société Internationale de Chirurgie 2013

Authors and Affiliations

  • Yoshiro Taguchi
    • 1
  • Tomoki Ebata
    • 1
  • Yukihiro Yokoyama
    • 1
  • Tsuyoshi Igami
    • 1
  • Gen Sugawara
    • 1
  • Toshio Kokuryo
    • 1
  • Kenji Wakai
    • 2
  • Masato Nagino
    • 1
    Email author
  1. 1.Division of Surgical Oncology, Department of SurgeryNagoya University Graduate School of MedicineNagoyaJapan
  2. 2.Department of Preventive MedicineNagoya University Graduate School of MedicineNagoyaJapan

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