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World Journal of Surgery

, Volume 37, Issue 11, pp 2561–2568 | Cite as

Impact of Obesity on Postoperative and Long-term Outcomes in a General Surgery Population: A Retrospective Cohort Study

  • Tabita M. Valentijn
  • Wael Galal
  • Sanne E. Hoeks
  • Yvette R. van Gestel
  • Hence J. Verhagen
  • Robert J. StolkerEmail author
Article

Abstract

Background

The obesity paradox has been demonstrated postoperatively in several surgical populations, but only a few studies have reported long-term survival. This study evaluates the presence of the obesity paradox in a general surgery population, reporting both postoperative and long-term survival.

Methods

This retrospective study included 10,427 patients scheduled for elective, noncardiac surgery. Patients were classified as underweight (body mass index (BMI) < 18.5 kg/m2); normal weight (BMI 18.5–24.9 kg/m2); overweight (BMI 25.0–29.9 kg/m2); obesity class I (BMI 30.0–34.9 kg/m2); obesity class II (BMI 35.0–39.9 kg/m2); and obesity class III (BMI ≥ 40.0 kg/m2). Study endpoints were 30-day postoperative and long-term mortality, including cause-specific mortality. Multivariable analyses were used to evaluate mortality risks for each BMI category.

Results

Within 30 days after surgery, 353 (3.4 %) patients died. Overweight was the only category associated with postoperative mortality, showing improved survival [odds ratio 0.7; 95 % confidence interval (CI) 0.6–0.9]. During the long-term follow-up 4,884 (47 %) patients died. Underweight patients had the highest mortality risk [hazard ratio (HR) 1.4; 95 % CI 1.2–1.6), particularly due to high cancer-related deaths. In contrast, overweight and obese patients demonstrated improved survival (overweight: HR 0.8, 95 % CI 0.8–0.9; obesity class I: HR 0.7, 95 % CI 0.7–0.8; obesity class II: HR 0.7, 95 % CI 0.6–0.9; obesity class III: HR 0.7, 95 % CI 0.5–1.0), mainly because of a strongly reduced risk of cancer-related death.

Conclusions

In this surgical population the obesity paradox was validated at the long term, mainly because of decreased cancer-related deaths among obese patients.

Keywords

Body Mass Index Chronic Obstructive Pulmonary Disease Obese Patient Body Mass Index Category Baseline Body Mass Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Dr. Valentijn is supported by an unrestricted research grant from “Lijf en Leven,” Rotterdam, The Netherlands.

Conflict of interest

The authors declare no conflicts of interest.

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Copyright information

© Société Internationale de Chirurgie 2013

Authors and Affiliations

  • Tabita M. Valentijn
    • 1
    • 2
  • Wael Galal
    • 1
    • 2
  • Sanne E. Hoeks
    • 1
  • Yvette R. van Gestel
    • 1
    • 3
  • Hence J. Verhagen
    • 2
  • Robert J. Stolker
    • 1
    Email author
  1. 1.Department of AnesthesiologyErasmus University Medical CenterRotterdamThe Netherlands
  2. 2.Department of Vascular SurgeryErasmus University Medical CenterRotterdamThe Netherlands
  3. 3.Eindhoven Cancer RegistryComprehensive Cancer Center South (IKZ)EindhovenThe Netherlands

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