World Journal of Surgery

, Volume 37, Issue 6, pp 1303–1312 | Cite as

Management of Hemangioma of the Liver: Surgical Therapy or Observation?

  • Süleyman Yedibela
  • Sedat Alibek
  • Volker Müller
  • Ünal Aydin
  • Melanie Langheinrich
  • Clemens Lohmüller
  • Werner Hohenberger
  • Aristotelis PerrakisEmail author



Elective surgery for liver hemangioma is controversial. We reviewed long-term outcomes following elective hepatectomy or observation only for symptomatic and asymptomatic liver hemangioma.


All patients (n = 307) with liver hemangioma referred to our hospital for surgical evaluation from January 1988 to December 2009 were identified, and imaging results, tumor characteristics, surgical indication, surgical mode, outcome of observation, clinical and/or postoperative outcome, and adverse events were retrospectively evaluated.


Complete median follow-up for 246 patients was 124 months. Elective surgery was performed in 103 patients (symptomatic [n = 62] and asymptomatic [n = 41]). Postoperative morbidity occurred in 17 % of the patients and was significantly lower in asymptomatic patients (p = 0.002). No perioperative mortality was registered. Surgery relieved complaints in most (88 %) patients. In the observation group (n = 143), 56 % of patients had persistent or new onset of hemangioma-associated symptoms. Major hemangioma-related complications occurred in 12 patients (9 %) during the follow-up period, and 2 patients died after traumatic hemangioma rupture. Overall the rate of adverse events was by trend lower in the surgical group than in the observation group (35 versus 57 %; p = 0.08).


The majority of patients with liver hemangioma can be safely managed by clinical observation. In a subset of patients, especially those with giant hemangioma and/or occurrence of symptoms, surgical treatment could be considered and is justified in high-volume centers.


Hemangioma Observation Group Cavernous Hemangioma Pringle Maneuver Traumatic Rupture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest



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Copyright information

© Société Internationale de Chirurgie 2013

Authors and Affiliations

  • Süleyman Yedibela
    • 1
  • Sedat Alibek
    • 2
  • Volker Müller
    • 1
  • Ünal Aydin
    • 3
  • Melanie Langheinrich
    • 1
  • Clemens Lohmüller
    • 1
  • Werner Hohenberger
    • 1
  • Aristotelis Perrakis
    • 1
    Email author
  1. 1.Department of SurgeryUniversity of Erlangen-NurembergErlangenGermany
  2. 2.Department of RadiologyUniversity of Erlangen-NurembergErlangenGermany
  3. 3.Department of SurgeryUniversity of GaziantepSehitkamil/GaziantepTurkey

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