World Journal of Surgery

, Volume 37, Issue 3, pp 582–590 | Cite as

Long-Term Outcome of Laparoscopic Surgery for Pancreatic Neuroendocrine Tumors

  • Sven-Petter HaugvikEmail author
  • Irina Pavlik Marangos
  • Bård Ingvald Røsok
  • Ewa Pomianowska
  • Ivar Prydz Gladhaug
  • Øystein Mathisen
  • Bjørn Edwin



As most pancreatic neuroendocrine tumors (PNET) are relatively small and solitary, they may be considered well suited for removal by a minimally invasive approach. There are few large series that describe laparoscopic surgery for PNET. The primary aim of this study was to describe the feasibility, outcome, and histopathology associated with laparoscopic pancreatic surgery (LS) of PNET in a large series.


All patients with PNET who underwent LS at a single hospital from March 1997 to April 2011 were included retrospectively in the study.


A total of 72 patients with PNET underwent 75 laparoscopic procedures, out of which 65 were laparoscopic resections or enucleations. The median operative time of all patients who underwent resections or enucleations was 175 (60–520) min, the median blood loss was 300 (5–2,700) ml, and the median length of hospital stay was 7 (2–27) days. The overall morbidity rate was 42 %, with a surgical morbidity rate of 21 % and postoperative pancreatic fistula (POPF) formation in 21 %. Laparoscopic enucleations were associated with a higher rate of POPF than were laparoscopic resections. Five-year disease-specific survival rate was 90 %. The T stage, R stage, and a Ki-67 cutoff value of 5 % significantly predicted 5-year survival.


LS of PNET is feasible with acceptable morbidity and a good overall disease-specific long-term prognosis.


Pancreatic Fistula Pancreatic Head Main Pancreatic Duct Pancreatic Neuroendocrine Tumor Pancreatic Body 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors thank Krzysztof Grzyb, MD, for playing an important role in the histopathological assessment of the surgical specimens. The sources of support behind this study came from Oslo University Hospital. There were no other sources of support.

Conflict of interest

The authors have no conflicts of interest to disclose.


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Copyright information

© Société Internationale de Chirurgie 2012

Authors and Affiliations

  • Sven-Petter Haugvik
    • 1
    • 2
    Email author
  • Irina Pavlik Marangos
    • 3
  • Bård Ingvald Røsok
    • 1
  • Ewa Pomianowska
    • 1
    • 2
  • Ivar Prydz Gladhaug
    • 1
    • 2
  • Øystein Mathisen
    • 1
  • Bjørn Edwin
    • 1
    • 2
    • 3
  1. 1.Department of Hepato-Pancreato-Biliary SurgeryRikshospitalet, Oslo University HospitalOsloNorway
  2. 2.Institute of Clinical MedicineUniversity of OsloOsloNorway
  3. 3.Interventional CentreRikshospitalet, Oslo University HospitalOsloNorway

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