World Journal of Surgery

, Volume 37, Issue 2, pp 452–458 | Cite as

Long-term Outcome after Liver Resection for Hepatocellular Carcinoma Larger than 10 cm

  • Pierre Allemann
  • Nicolas DemartinesEmail author
  • Hanifah Bouzourene
  • Adrien Tempia
  • Nermin Halkic



The purpose of the present study was to analyze long-term survival and disease-free survival after liver resection for giant hepatocellular carcinoma (HCC) ≥ 10 cm compared to HCC < 10 cm in diameter. The surgical approach in the treatment of giant HCC may achieve long-term survival and disease-free survival comparable to treatment of smaller lesions.


This retrospective analysis was a monocentric study conducted in a tertiary university center. It included 101 patients from 114 consecutive liver resections for HCC, separated into two groups: those with tumors less than 10 cm in diameter (small HCC; n = 79) and those with tumors larger than 10 cm (giant HCC; n = 22). The main outcome measures were overall five-year survival, five-year disease-free survival, recurrence rate, perioperative mortality at 30 days, surgical complication rate, and re-intervention rate.


The two groups were homogeneously distributed, apart from cirrhosis, which was found more frequently in the group with small HCC (77 vs. 41 %; p = 0.0013). Both median survival (24 vs. 27 months; p = 0.0085) and overall 5-year survival (21 vs. 45; p = 0.04) were significantly poorer in the small HCC group compared to the giant HCC group. There were no differences en terms of recurrence rate, pattern, and timing.


Liver resection for HCC larger than 10 cm is a valuable option in selected patients, one that provides overall survival and disease-free survival comparable to smaller lesions. Functional reserves of the liver, more than the size of the lesion, may be important in patient selection for surgical resection.


Liver Resection Tace Primary Biliary Cirrhosis Functional Reserve Transcatheter Arterial Chemoembolization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Société Internationale de Chirurgie 2012

Authors and Affiliations

  • Pierre Allemann
    • 1
  • Nicolas Demartines
    • 1
    Email author
  • Hanifah Bouzourene
    • 2
  • Adrien Tempia
    • 1
  • Nermin Halkic
    • 1
  1. 1.Department of Visceral Surgery and TransplantationUniversity Hospital CHUVLausanneSwitzerland
  2. 2.Department of PathologyUniversity Hospital CHUVLausanneSwitzerland

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