World Journal of Surgery

, Volume 36, Issue 12, pp 2923–2930

Impact of Posttransplantation Glomerulonephritis on Long-term Outcome of Kidney Transplants: Single-Center 20-Year Experience

  • Tung-Min Yu
  • Mei-Chin Wen
  • Ming-Ju Wu
  • Cheng-Hsu Chen
  • Chi-Hung Cheng
  • Chi-Yuan Li
  • Kuo-Hsiung Shu



Successful renal transplantation has been performed in patients with end-stage renal disease and has been routine in patients with end-stage renal failure for more than two decades. Despite advances in the use of immunosuppressants, there has been only modest improvement in long-term allograft survival. Accumulating data have demonstrated that chronic rejection and recurrent glomerulonephritis are major causes of long-term allograft loss. However, data regarding the long-term impact of posttransplantation glomerulonephritis (PTGN) on ethnic Chinese populations are still unavailable.


From 1984 to 2010, a total of 268 patients who underwent renal allograft biopsies were reviewed retrospectively. Renal outcomes were compared by Kaplan–Meier analysis, and risk factors for renal survival and all-cause mortality were analyzed using the Cox proportional hazards model.


In all, 85 patients (31.7 %) had PTGN, and the mean time of disease onset was 5.32 ± 5.18 years after transplantation. Among the 85 PTGN cases, 33 (39 %) were immunoglobulin A (IgA) nephropathy, 24 (28 %) were focal segmental glomerulosclerosis, and 8 (9.4 %) were membranous GN. Significant risk was associated with posttransplant IgA GN in hepatitis B virus carriers (odds ratio 5.371, 95 % confidence interval 1.68, 17.19; p = 0.0064). A total of 45 PTGN patients had allograft loss, of whom 49 % had IgA nephropathy. Patients with PTGN had inferior allograft survival rates compared to those with other pathologic findings (p < 0.0003).


Taken together, our results indicate that PTGN had a strong negative impact on long-term kidney graft survival. Posttransplant IgA nephropathy is a leading cause of allograft loss in Chinese kidney transplant patients with PTGN.


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Copyright information

© Société Internationale de Chirurgie 2012

Authors and Affiliations

  • Tung-Min Yu
    • 1
    • 3
  • Mei-Chin Wen
    • 2
  • Ming-Ju Wu
    • 1
  • Cheng-Hsu Chen
    • 1
  • Chi-Hung Cheng
    • 1
  • Chi-Yuan Li
    • 3
  • Kuo-Hsiung Shu
    • 1
    • 4
  1. 1.Division of Nephrology, Department of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan
  2. 2.Department of PathologyTaichung Veteran General HospitalTaichungTaiwan
  3. 3.Graduate Institute of Clinical Medical ScienceChina Medical UniversityTaichungTaiwan
  4. 4.Chung-Shan Medical UniversityTaichungTaiwan

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