World Journal of Surgery

, Volume 36, Issue 5, pp 1016–1029

Somatostatin Analogues for the Treatment of Enterocutaneous Fistulas: A Systematic Review and Meta-analysis

  • Shaun Coughlin
  • Lee Roth
  • Giovanna Lurati
  • Markus Faulhaber
Article

DOI: 10.1007/s00268-012-1494-3

Cite this article as:
Coughlin, S., Roth, L., Lurati, G. et al. World J Surg (2012) 36: 1016. doi:10.1007/s00268-012-1494-3

Abstract

Background

Enterocutaneous fistulas are abnormal connections between the skin and gastrointestinal tract that most commonly occur after surgery. Somatostatin analogues have been used in their treatment. The objective of the present study was to determine if somatostatin analogues shorten the time to closure of postoperative enterocutaneous fistulas compared to placebo.

Methods

We searched Medline, EMBase, the Cochrane Central Register of Controlled Trials, as well as reference lists of textbooks and relevant articles for randomized controlled trials (RCT) comparing somatostatin analogues to control in the treatment of postoperative enterocutaneous fistulas. We systematically assessed trials for eligibility and validity, and extracted data in duplicate. We pooled data across studies using a random effects model.

Results

Our initial search yielded 720 studies, of which eight RCT ultimately met eligibility criteria and were included in this review. Somatostatin analogues significantly decreased the time to closure of fistulas compared to placebo {weighted mean difference (WMD)—6.37 days [95% confidence interval (CI) −8.33, −4.42]}. The duration of hospital stay was also significantly decreased with somatostatin analogue treatment [WMD—4.53 days (95% CI −8.29, −0.77)]. No difference in mortality was identified with somatostatin treatment [RR 0.87 (95% CI 0.49–1.55)].

Conclusions

Somatostatin analogues appear to decrease the duration of enterocutaneous fistulas and duration of hospital stay, but no mortality benefit was identified. The quality of evidence for outcomes in this review ranged from low to moderate. Future large, blinded, RCT would be useful in improving the confidence in the treatment effects identified in this systematic review and meta-analysis.

Copyright information

© Société Internationale de Chirurgie 2012

Authors and Affiliations

  • Shaun Coughlin
    • 1
  • Lee Roth
    • 1
  • Giovanna Lurati
    • 2
  • Markus Faulhaber
    • 2
  1. 1.Department of General SurgeryUniversity of Western OntarioLondonCanada
  2. 2.McMaster UniversityHamiltonCanada

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