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A Predictive Model of Suitability for Minimally Invasive Parathyroid Surgery in the Treatment of Primary Hyperthyroidism

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An Erratum to this article was published on 02 March 2012

Abstract

Background

Improved preoperative localizing studies have facilitated minimally invasive approaches in the treatment of primary hyperparathyroidism (PHPT). Success depends on the ability to reliably select patients who have PHPT due to single-gland disease. We propose a model encompassing preoperative clinical, biochemical, and imaging studies to predict a patient’s suitability for minimally invasive surgery.

Methods

For the purposes of the present study, 180 consecutive patients were included for analysis. A 5-variable model based on preoperative ionized serum calcium (>1.4 mmol/l), intact parathyroid hormone level (≥2 times the upper limit of normal), positive sestamibi scan for a single affected gland, positive ultrasound scan for a single gland, and concordance between the two imaging modalities for single-gland disease at a similar location was employed, where a score of 1 was allocated for each variable present.

Results

Of the 180 patients, 62 (34%) underwent bilateral exploration, 63 (36%) underwent unilateral exploration, and 55 (30%) underwent minimally invasive parathyroidectomy. The results showed that 92% had single-gland disease, 3% had double adenomas, and 5% had hyperplasia. Biochemical cure was achieved in 98.9%. Mean follow-up was 153 days (range: 80–342 days). With the predictive scoring model, a score of ≥3 had a positive predictive value of 100% for single-gland disease.

Conclusions

A scoring model encompassing preoperative biochemical and imaging data can be successfully employed to predict suitability for minimally invasive surgery in the majority of patients with single-gland disease.

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Authors and Affiliations

  1. Department of Breast & Endocrine Surgery, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland

    Dara O. Kavanagh, Eddie Myers, Rory Kennelly, Arnold D. K. Hill, Denis Evoy & Enda W. McDermott

  2. Department of Medicine, Physiotherapy & Population Science, School of Public Health Medicine, University College Dublin, Belfield, Dublin 4, Ireland

    Patricia Fitzpatrick

  3. School of Medicine & Medical Science, University College Dublin, Belfield, Dublin 4, Ireland

    Patricia Fitzpatrick

  4. Department of Radiology, St. Vincents University Hospital, Elm Park, Dublin 4, Ireland

    Stephen J. Skehan & Robert G. Gibney

Authors
  1. Dara O. Kavanagh
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  2. Patricia Fitzpatrick
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  3. Eddie Myers
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  4. Rory Kennelly
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  5. Stephen J. Skehan
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  6. Robert G. Gibney
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  7. Arnold D. K. Hill
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  8. Denis Evoy
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  9. Enda W. McDermott
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Corresponding author

Correspondence to Dara O. Kavanagh.

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Kavanagh, D.O., Fitzpatrick, P., Myers, E. et al. A Predictive Model of Suitability for Minimally Invasive Parathyroid Surgery in the Treatment of Primary Hyperthyroidism. World J Surg 36, 1175–1181 (2012). https://doi.org/10.1007/s00268-011-1377-z

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  • DOI: https://doi.org/10.1007/s00268-011-1377-z

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