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World Journal of Surgery

, 35:2417 | Cite as

Large Clinical Experience of Primary Angiosarcoma of the Breast in a Single Korean Medical Institute

  • Soo Youn Bae
  • Min-Young Choi
  • Dong Hui Cho
  • Jeong Eon LeeEmail author
  • Seok Jin Nam
  • Jung-Hyun Yang
Article

Abstract

Background

Angiosarcoma of the breast is rare. The purpose of the present study was to evaluate the clinicopathologic characteristics and the clinical outcomes of patients with primary breast angiosarcoma.

Methods

We analyzed the clinicopathologic factors of patients with angiosarcoma of the breast treated between 1997 and 2010 at the Samsung Medical Center. We reviewed the related demographic data, preoperative imaging studies, method of histologic confirmation, tumor size, histologic grades, status of hormonal receptors, treatment modality, and survival data.

Results

Nine women with angiosarcoma of the breast were identified. The median age of patients with primary angiosarcoma of the breast at diagnosis was 31 years (range: 19–63 years), and the median tumor size was 9.0 cm (range: 3.5–10.7 cm). Seven patients (77.7%) died within a median follow-up of 46.7 months (range: 3.9–63.3 months), and all deaths were directly attributed to angiosarcoma. Overall, the median time from diagnosis of angiosarcoma to death was 46.8 months (range: 8.21–63.3 months). The 5 year overall survival with angiosarcoma was 42.9%.

Conclusions

Primary angiosarcoma of the breast is a rare malignancy with a poor prognosis, even with complete resection. Chemotherapy and radiation therapy have limited value as treatments to date. Total mastectomy appears to be the most appropriate and beneficial treatment. More aggressive surgical management should be considered, and future clinical research should explore the most appropriate adjuvant therapy in the treatment of angiosarcoma.

Keywords

Triple Negative Breast Cancer Angiosarcoma Total Mastectomy Primary Angiosarcoma Future Clinical Research 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health & Welfare Affairs, Republic of Korea (A092255).

References

  1. 1.
    Huang J, Mackillop WJ (2001) Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma. Cancer 92:172–180PubMedCrossRefGoogle Scholar
  2. 2.
    Vorburger SA, Xing Y, Hunt KK et al (2005) Angiosarcoma of the breast. Cancer 104:2682–2688PubMedCrossRefGoogle Scholar
  3. 3.
    Zelek L, Llombart-Cussac A, Terrier P et al (2003) Prognostic factors in primary breast sarcomas: a series of patients with long-term follow-up. J Clin Oncol 21:2583–2588PubMedCrossRefGoogle Scholar
  4. 4.
    Marchal C, Weber B, de Lafontan B et al (1999) Nine breast angiosarcomas after conservative treatment for breast carcinoma: a survey from French comprehensive Cancer Centers. Int J Radiat Oncol Biol Phys 44:113–119PubMedCrossRefGoogle Scholar
  5. 5.
    Chen KT, Kirkegaard DD, Bocian JJ (1980) Angiosarcoma of the breast. Cancer 46:368–371PubMedCrossRefGoogle Scholar
  6. 6.
    Donnell RM, Rosen PP, Lieberman PH et al (1981) Angiosarcoma and other vascular tumors of the breast. Am J Surg Pathol 5:629–642PubMedCrossRefGoogle Scholar
  7. 7.
    Hodgson NC, Bowen-Wells C, Moffat F et al (2007) Angiosarcomas of the breast: a review of 70 cases. Am J Clin Oncol 30:570–573PubMedCrossRefGoogle Scholar
  8. 8.
    West JG, Qureshi A, West JE et al (2005) Risk of angiosarcoma following breast conservation: a clinical alert. Breast J 11:115–123PubMedCrossRefGoogle Scholar
  9. 9.
    Luini A, Gatti G, Diaz J et al (2007) Angiosarcoma of the breast: the experience of the European Institute of Oncology and a review of the literature. Breast Cancer Res Treat 105:81–85PubMedCrossRefGoogle Scholar
  10. 10.
    Kiluk JV, Yeh KA (2005) Primary angiosarcoma of the breast. Breast J 11:517–518PubMedCrossRefGoogle Scholar
  11. 11.
    McGowan TS, Cummings BJ, O’Sullivan B et al (2000) An analysis of 78 breast sarcoma patients without distant metastases at presentation. Int J Radiat Oncol Biol Phys 46:383–390PubMedCrossRefGoogle Scholar
  12. 12.
    Lee SD, Han BK, Yang JH et al (2000) Angiosarcoma of the breast: a report of 2 cases. J Korean Surg Soc 58:851–856Google Scholar
  13. 13.
    Hunter TB, Martin PC, Dietzen CD et al (1985) Angiosarcoma of the breast two case reports and a review of the literature. Cancer 56:2099–2106PubMedCrossRefGoogle Scholar
  14. 14.
    Merino MJ, Carter D, Berman M (1983) Angiosarcoma of the breast. Am J Surg Pathol 7:53–60PubMedCrossRefGoogle Scholar
  15. 15.
    Cafiero F, Gipponi M, Peressini A et al (1996) Radiation-associated angiosarcoma: diagnostic and therapeutic implications—two case reports and a review of the literature. Cancer 77:2496–2502PubMedCrossRefGoogle Scholar
  16. 16.
    Feigenberg SJ, Mendenhall NP, Reith JD et al (2002) Angiosarcoma after breast-conserving therapy: experience with hyperfractionated radiotherapy. Int J Radiat Oncol Biol Phys 52:620–626PubMedCrossRefGoogle Scholar
  17. 17.
    Mandrell J, Mehta S, McClure S (2010) Atypical vascular lesion of the breast. J Am Acad Dermatol 63:337–340PubMedCrossRefGoogle Scholar
  18. 18.
    Scow JS, Reynolds CA, Degnim AC et al (2010) Primary and secondary angiosarcoma of the breast: the Mayo Clinic experience. J Surg Oncol 101:401–407PubMedGoogle Scholar
  19. 19.
    Monroe AT, Feigenberg SJ, Mendenhall NP (2003) Angiosarcoma after breast-conserving therapy. Cancer 97:1832–1840PubMedCrossRefGoogle Scholar
  20. 20.
    Nakamura R, Nagashima T, Sakakibara M et al (2007) Angiosarcoma arising in the breast following breast-conserving surgery with radiation for breast carcinoma. Breast Cancer 14:245–249PubMedCrossRefGoogle Scholar
  21. 21.
    Sher T, Hennessy BT, Valero V et al (2007) Primary angiosarcomas of the breast. Cancer 110:173–178PubMedCrossRefGoogle Scholar
  22. 22.
    Yang WT, Hennessy BT, Dryden MJ et al (2007) Mammary angiosarcomas: imaging findings in 24 patients. Radiology 242:725–734PubMedCrossRefGoogle Scholar
  23. 23.
    Kim YJ, Lee KH, Cho YU et al (2006) MR imaging and spectroscopic findings of primary angiosarcoma of the breast: a case report. J Korean Radiol Soc 54:557–560Google Scholar
  24. 24.
    Nagano T, Yamada Y, Ikeda T et al (2007) Docetaxel: a therapeutic option in the treatment of cutaneous angiosarcoma: report of 9 patients. Cancer 110:648–651PubMedCrossRefGoogle Scholar
  25. 25.
    Blay JY, Le Cesne A (2009) Adjuvant chemotherapy in localized soft tissue sarcomas: still not proven. Oncologist 14:1013–1020PubMedCrossRefGoogle Scholar
  26. 26.
    Perez-Ruiz E, Ribelles N, Sanchez-Munoz A et al (2009) Response to paclitaxel in a radiotherapy-induced breast angiosarcoma. Acta Oncol 48:1078–1079PubMedCrossRefGoogle Scholar

Copyright information

© Société Internationale de Chirurgie 2011

Authors and Affiliations

  • Soo Youn Bae
    • 1
  • Min-Young Choi
    • 2
  • Dong Hui Cho
    • 2
  • Jeong Eon Lee
    • 2
    Email author
  • Seok Jin Nam
    • 2
  • Jung-Hyun Yang
    • 1
  1. 1.Department of SurgeryKonkuk University Medical Center, Konkuk University School of MedicineSeoulRepublic of Korea
  2. 2.Department of SurgerySamsung Medical Center, Sungkyunkwan University School of MedicineSeoulRepublic of Korea

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