A Primer on a Hepatocellular Carcinoma Bioresource Bank Using the Cancer Genome Atlas Guidelines: Practical Issues and Pitfalls
- 153 Downloads
Since the advent of the human genome, the era of personalized genomic medicine is indisputably in progress.
In an effort to contribute to the evolving knowledge of genomic medicine, we have aimed directly at building a bioresource bank for hepatocellular carcinoma. This tumor bank is based on the rigorous guidelines set forth by the National Cancer Institute, and it offers analytes to help elucidate the mechanisms of progression from cirrhosis to malignancy, risk factors for recurrence, and applicability of current treatment options to a diverse group of people.
Surgeons have a privileged position between patients (and their cancer) and the benches of basic science. Thus, we offer a primer based on our own experiences, from which surgeons may take elements to build their own bioresource bank for use in collaboration with others. We highlight some practicalities and pitfalls that could be overlooked, as well as a discussion of possible solutions.
KeywordsTace Tissue Bank Comprehensive Cancer Center Common Data Element Cryogenic Vial
The authors are grateful to the members of the Human Genome Sequencing Center, who helped to make this manuscript, not the least of which is the Bioinformatics division. We are thankful for the dedication, expertise and support of Drs. Dolores Lopez-Terrada and Milton Finegold of the Department of Pathology at Baylor College of Medicine. Special thanks are owed to the Liver Center, the Hepatobiliary faculty, and all the residents at the Michael E. DeBakey Department of General Surgery, who tirelessly care for our patients. And, of course, we are grateful to our patients, without whom this research could not exist and whose sacrifices will not be taken for granted. This study was supported in part by grants from National Institutes of Health (NIH) U54-HG003273, U54-HG004973 (to R.A.G.); and Cancer Prevention & Research Institution of Texas (CPRIT) grant RP101353-P01/P07 (also to R.A.G.).
- 7.ISBER (2008) Best practices for repositories. Cell Preserv Technol. Available at http://www.isber.org/ibc.html. Accessed December 30, 2010
- 13.Office of Biorepositories and Biospecimen Research. Available at http://biospecimens.cancer.gov/default.asp. Accessed October 15, 2010
- 14.The Cancer Human Biobank. Available at http://cahub.cancer.gov/. Accessed October 15, 2010
- 15.NCI Best Practices for Biospecimen Resources (Office of Biorepositories and Biospecimen Research, NCI, NIH, US DHHS, 2010)Google Scholar
- 20.Knoppers BM (2005) Biobanking: international norms. Regulation of biobanks. J Law Med Ethics 33(Spring):7–14Google Scholar