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World Journal of Surgery

, Volume 34, Issue 10, pp 2418–2425 | Cite as

Does Pringle Maneuver Affect Survival in Patients with Colorectal Liver Metastases?

  • Alessandro FerreroEmail author
  • Nadia Russolillo
  • Luca Viganò
  • Roberto Lo Tesoriere
  • Andrea Muratore
  • Lorenzo Capussotti
Article

Abstract

Background

The purpose of this original article was to evaluate the impact of the Pringle maneuver on the survival of patients with colorectal liver metastases.

Methods

Eighty patients with colorectal liver metastases were randomized to undergo hepatectomy with (39 patients, HPC group) or without (41 patients, NHPC group) pedicle clamping.

Results

The two groups were homogeneous. Mortality and morbidity rates were similar. Blood transfusions rates were higher in HPC group (p = 0.010). Median follow-up was 67.1 ± 20 months in the HPC group and 77.5 ± 16.6 months in the other group (p = 0.07). Overall survival at 1, 3, and 5 years was 100%, 86.1%, and 49.4% in HPC group vs. 92.6%, 65.8%, and 48.2% in NHPC group (p = 0.704). Disease-free survival was similar between the two groups: 1-, 3- and 5-year survival rates were 85.7%, 51.4%, and 34.3% in the HPC group vs. 84%, 51.5%, and 37.9% in NHPC group (p = 0.943). The incidence of hepatic recurrence was similar in the two groups (p = 0.506). Median time to hepatic recurrence was similar in the two groups (p = 0.482). Overall and disease-free survival rates were similar even when the Pringle maneuver was longer than 45 min (p = 0.571 and 0.948) and in patients with liver steatosis (p = 0.779 and 0.412).

Conclusions

The Pringle maneuver does not seem to affect the survival of patients with liver metastases.

Keywords

Liver Resection Colorectal Liver Metastasis Future Remnant Liver Liver Steatosis Pringle Maneuver 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Société Internationale de Chirurgie 2010

Authors and Affiliations

  • Alessandro Ferrero
    • 1
    Email author
  • Nadia Russolillo
    • 1
  • Luca Viganò
    • 1
  • Roberto Lo Tesoriere
    • 1
  • Andrea Muratore
    • 1
  • Lorenzo Capussotti
    • 1
  1. 1.Department of SurgeryOspedale Mauriziano “Umberto I”TurinItaly

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