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World Journal of Surgery

, Volume 34, Issue 9, pp 2057–2063 | Cite as

Splanchnic Vasoregulation After Major Abdominal Surgery in Pigs

  • Lukas E. Brügger
  • Guido Beldi
  • Mario Beck
  • Francesca Porta
  • Hendrik Bracht
  • Daniel Candinas
  • Jukka Takala
  • Stephan M. JakobEmail author
Article

Abstract

Background

Unrecognized reduction of blood supply to intestinal organs is associated with significant postoperative morbidity in abdominal surgery. The aim of this study was to determine whether—in the absence of hypovolemia—intestinal hypoperfusion as a result of blood flow redistribution occurs after abdominal surgery.

Methods

Standardized operative trauma was induced in 14 healthy pigs. Systemic, regional, and local blood flow, intestinal and gastric intraluminal-to-end-tidal pCO2 gradients representing mucosal perfusion, and oxygen transport variables were measured for 10 postoperative hours. Normovolemia was maintained using continuous infusion of Ringer’s lactate and additional boluses of colloids in response to blood pressure, pulmonary wedge pressure, and urinary output.

Results

Postoperative blood flow was significantly increased in the celiac trunk (76% increase [percentage of baseline flow], p = 0.003) and the hepatic (136% increase, p = 0.002) and splenic (36% increase, p = 0.025) arteries. Blood flow was significantly decreased in the mesenteric artery (25% decrease, p = 0.007) and portal vein (13% decrease, p = 0.028). Carotid and renal artery blood flow remained unchanged.

Conclusions

Maintenance of normovolemia is insufficient to protect from intestinal hypoperfusion after abdominal surgery. Postoperative redistribution of cardiac output results in decreased intestinal and increased hepatic and splenic arterial blood flow.

Keywords

Superior Mesenteric Artery Celiac Trunk Pulmonary Artery Occlusion Pressure Blood Flow Redistribution pCO2 Gradient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This work was funded by the Swiss National Fund for Scientific Research (SNF 3200BO-102268).

Conflicts of interest

None.

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Copyright information

© Société Internationale de Chirurgie 2010

Authors and Affiliations

  • Lukas E. Brügger
    • 1
  • Guido Beldi
    • 1
  • Mario Beck
    • 2
  • Francesca Porta
    • 2
  • Hendrik Bracht
    • 2
  • Daniel Candinas
    • 1
  • Jukka Takala
    • 2
  • Stephan M. Jakob
    • 2
    Email author
  1. 1.Department of Visceral Surgery and MedicineBern University Hospital and University of BernBernSwitzerland
  2. 2.Department of Intensive Care MedicineBern University Hospital and University of Bern (Inselspital)BernSwitzerland

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