World Journal of Surgery

, Volume 34, Issue 5, pp 1052–1058 | Cite as

Platelet Transfusion can be Related to Liver Regeneration After Living Donor Liver Transplantation

  • Joohyun Kim
  • Nam-Joon Yi
  • Woo Young Shin
  • Taehoon Kim
  • Kuhn Uk Lee
  • Kyung-Suk Suh
Article

Abstract

Background

Although liver regeneration is a fundamental aspect of living donor liver transplantation (LDLT), the factors that affect liver regeneration during the early post-transplantation period have not been thoroughly investigated. Recently it was suggested that platelets contribute to liver regeneration. The aim of the present study was to identify the major factors that affect liver graft regeneration during the early post-transplantation period.

Materials and methods

Eighty-seven right liver grafted, adult-to-adult LDLT patients were retrospectively analyzed. Liver regeneration was assessed by volumetry from computed tomographic (CT) scans obtained between the 9th and 11th postoperative days. The authors investigated relationships between clinical variables and liver graft regeneration rates, and they conducted multiple regression analysis on factors found to be significant by univariate analysis.

Results

Mean graft weight at operation was 722.9 ± 109.7 g, and mean graft volume assessed by follow-up CT was 1,042.2 ± 155.6 ml, reflecting a mean liver graft regeneration of 45.9 ± 22.3%. The graft regeneration was found to correlate inversely with graft-to-recipient weight ratio (GRWR, r = −0.406, p < 0.001) and directly with portal flow velocity (cm/s; r = 0.307; p = 0.004) and splenic index (cm3; r = 0.282; p = 0.009). Moreover, the total amount (units) of platelets transfused was found to be significantly associated with graft regeneration (r = 0.293; p = −.006). Stepwise regression analysis showed that GRWR (β = −33.124; p = 0.001), total amount of platelets transfused (β = 0.771; p = 0.012), and splenic index (β = −0.010; p = 0.049) were independently associated with graft regeneration.

Conclusions

The results of the present study suggest that platelets play a significant role in human liver regeneration after LDLT.

Notes

Acknowledgments

We appreciate the statistical assistance provided by the Medical Research Collaborating Center at Seoul National University College of Medicine/Seoul National University Hospital.

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Copyright information

© Société Internationale de Chirurgie 2010

Authors and Affiliations

  • Joohyun Kim
    • 1
  • Nam-Joon Yi
    • 2
  • Woo Young Shin
    • 2
  • Taehoon Kim
    • 2
  • Kuhn Uk Lee
    • 2
  • Kyung-Suk Suh
    • 2
  1. 1.Department of Surgery, Kyung Hee University Medical CenterKyung Hee University College of MedicineSeoulRepublic of Korea
  2. 2.Department of SurgerySeoul National University College of Medicine, Seoul National University HospitalSeoulRepublic of Korea

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