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World Journal of Surgery

, Volume 34, Issue 6, pp 1254–1260 | Cite as

Diagnostic Utility of Fine-Needle Aspiration Cytology in Pediatric Differentiated Thyroid Cancer

  • Anna E. Bargren
  • Goswin Y. Meyer-Rochow
  • Mark S. Sywak
  • Leigh W. Delbridge
  • Herbert Chen
  • Stan B. Sidhu
Article

Abstract

Background

Pediatric patients present with thyroid nodules less often than adults, but the rate of malignancy is much higher. This study was designed to determine the ability of fine-needle aspiration cytology (FNA) to diagnose accurately and facilitate management of thyroid neoplasms in pediatric patients.

Methods

A retrospective study revealed 110 patients <19 years old who had undergone thyroid surgery and FNA biopsy at two academic institutions over the last 28 years. FNA sensitivity for diagnosing papillary thyroid cancer (PC) and follicular neoplasm (FN) was investigated.

Results

Of 110 patients who presented for surgery, 27 had PC and 33 had a FN: 4 follicular carcinomas (FCs) and 29 follicular adenomas (FAs). Among the PCs patients, the FNA results were as follows: 1 (4%) nondiagnostic, 6 (22%) atypical, 2 (7%) benign, and 18 (67%) malignant lesions. The sensitivity of a malignant FNA was 90% for diagnosing a PC. Sensitivity of an atypical FNA was 75% for FCs and 69% for FAs, giving an overall FN sensitivity of 70%. Of the atypical FNA readings, 60% had confirmed histological atypical features, and 19% were malignant. In 95% of the malignant FNA reports, final histology confirmed PC, resulting in a positive predictive value of 95%.

Conclusions

FNA biopsy can reliably diagnose malignancy in pediatric thyroid patients and should be used as a standard technique to indicate surgical treatment. Atypical or suspicious FNA results do not predict cancer effectively, confirming the current accepted practice for adults that diagnostic excision is required to exclude malignancy in pediatric patients.

Keywords

Thyroid Cancer Thyroid Nodule Total Thyroidectomy Papillary Thyroid Cancer Follicular Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors thank Pamela Edhouse, University of Sydney Endocrine Surgical Department, Royal North Shore Hospital, St. Leonards, NSW, Australia, for her assistance with patient data acquisition.

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Copyright information

© Société Internationale de Chirurgie 2010

Authors and Affiliations

  • Anna E. Bargren
    • 1
  • Goswin Y. Meyer-Rochow
    • 2
  • Mark S. Sywak
    • 2
  • Leigh W. Delbridge
    • 2
  • Herbert Chen
    • 1
  • Stan B. Sidhu
    • 2
  1. 1.Section of Endocrine Surgery, Department of SurgeryH4/722 Clinical Science Center, University of WisconsinMadisonUSA
  2. 2.Endocrine Surgical UnitUniversity of SydneySt. LeonardsAustralia

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