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World Journal of Surgery

, 33:1298 | Cite as

Effect of Preoperative Hyperfibrinogenemia on Recurrence of Colorectal Cancer Without a Systemic Inflammatory Response

  • Hiroharu Yamashita
  • Joji Kitayama
  • Masataka Taguri
  • Hirokazu Nagawa
Article

Abstract

Background

Disorders in the blood coagulation system are often associated with malignancy. Patients with colorectal cancer (CRC) have been shown to have abnormal data for various coagulation tests.

Methods

We retrospectively analyzed the relation between the preoperative plasma fibrinogen level and tumor recurrence in 569 patients with CRC who underwent curative surgical resection and were followed up without adjuvant chemotherapy.

Results

The plasma fibrinogen level showed a positive association with tumor recurrence, age, sex, T stage, and TNM classification. When divided with the median value, hyperfibrinogenemia is positively correlated with tumor recurrence, although it lost independence in the multivariate analysis. In the C-reactive protein (CRP)-negative population, hyperfibrinogenemia is independently correlated with tumor recurrence and recurrence-free survival. In contrast, hyperfibrinogenemia has no effect on recurrence in CRP-positive patients.

Conclusions

Hyperfibrinogenemia is clinically relevant in tumor recurrence before a systemic inflammatory response and thus can be a useful predictor of recurrence in the preinflammatory stage of CRC.

Keywords

Fibrinogen Tumor Recurrence Plasma Fibrinogen Level Ciprofibrate Fibrinogen Degradation Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan and by a grant from the Ministry of Health and Welfare of Japan.

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Copyright information

© Société Internationale de Chirurgie 2009

Authors and Affiliations

  • Hiroharu Yamashita
    • 1
  • Joji Kitayama
    • 1
  • Masataka Taguri
    • 2
  • Hirokazu Nagawa
    • 1
  1. 1.Department of Surgical OncologyThe University of Tokyo, Graduate School of MedicineTokyoJapan
  2. 2.Department of BiostatisticsThe University of Tokyo, Graduate School of MedicineTokyoJapan

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