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World Journal of Surgery

, Volume 34, Issue 1, pp 85–91 | Cite as

Ratio Between Metastatic and Examined Lymph Nodes (N Ratio) May Have Low Clinical Utility in Gastric Cancer Patients Treated by Limited Lymphadenectomy: Results from a Single-Center Experience of 526 Patients

  • Corrado PedrazzaniEmail author
  • Armands SivinsEmail author
  • Guntis Ancans
  • Daniele Marrelli
  • Giovanni Corso
  • Viesturs Krumins
  • Franco Roviello
  • Marcis Leja
Article

Abstract

Background

The aim of this study was to evaluate the prognostic value of the ratio of metastatic to examined lymph nodes (N ratio) in gastric cancer patients who underwent limited lymphadenectomy and had a small number (≤15) of analyzed nodes.

Methods

The prognostic value of the actual AJCC/UICC pN staging system and the N ratio (0%, 1–25%, > 25%) were analyzed by means of univariate and multivariate analyses for 526 patients who underwent R0 resection for gastric adenocarcinoma at the Latvia Oncology Center.

Results

The mean (SD) number of analyzed nodes was 5.6 (2.8). The number of positive nodes significantly increased with the number of analyzed nodes (p < 0.001). No significant differences in survival (p = 0.508) and risk of death (p = 0.224) were observed between pN1 and pN2 subsets. When the N ratio (1–25% vs. > 25%) was taken into account, a significant difference was demonstrated between pNR1 and pNR2 with respect to survival (p = 0.017) and risk of death (p = 0.012). Nonetheless, the joint allocation of the two classifications demonstrated that only a minority of patients (28 cases) belonged to the pNR1 subset and none of these belonged to the AJCC/UICC pN2 subset.

Conclusions

When a small number of lymph nodes are analyzed, the N ratio can discriminate patients better than TNM classification. However, because a small number of retrieved nodes produced only a small number of pNR1 patients, the N ratio classification cannot be justified for clinical use.

Keywords

Lymph Node Gastric Cancer Gastric Cancer Patient Metastatic Node Stage Migration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Société Internationale de Chirurgie 2009

Authors and Affiliations

  • Corrado Pedrazzani
    • 1
    • 4
    Email author
  • Armands Sivins
    • 2
    • 3
    Email author
  • Guntis Ancans
    • 2
    • 3
  • Daniele Marrelli
    • 1
  • Giovanni Corso
    • 1
  • Viesturs Krumins
    • 2
    • 3
  • Franco Roviello
    • 1
  • Marcis Leja
    • 2
    • 3
  1. 1.Department of Human Pathology and Oncology, Unit of Surgical OncologyUniversity of SienaSienaItaly
  2. 2.Riga Eastern University Hospital, Latvia Oncology CenterRigaLatvia
  3. 3.University of LatviaRigaLatvia
  4. 4.Dipartimento di Patologia Umana e OncologiaSezione di Chirurgia Oncologica, Policlinico ‘Le Scotte’ (I lotto, V piano)SienaItaly

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