Fibrin Sealant: Past, Present, and Future: A Brief Review
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Fibrin sealant is a two-component topical hemostat, sealant, and tissue adhesive consisting of fibrinogen and thrombin that has been used in the United States as a blood bank- or laboratory-derived product since the 1980s and has been commercially available since 1998.
Initially, surgeons employed hospital-based materials because of the lack of availability of a commercially produced agent. At present, there are five U.S. Food and Drug Administration (FDA)-approved forms including products derived from pooled or autologous human plasma as well as bovine plasma. On-label indications include hemostasis, colonic sealing, and skin graft attachment. Recent clinical and experimental uses include tissue or mesh attachment, fistula closure, lymphatic sealing, adhesion prevention, drug delivery, and tissue engineering.
The modern literature on fibrin sealant now exceeds 3000 articles and continues to expand. This brief review presents the history of this material, its present clinical use, and its future applications.
KeywordsFibrinogen Fibrin Glue Fibrin Sealant Fistula Closure Colostomy Closure
The author thanks Dr. Eric Rose for his interest in fibrin sealant at the Columbia Presbyterian Medical Center during the1980s, which facilitated the author’s exploration of the clinical and experimental use of this material.
- 2.Spotnitz WD, Prabhu R, Welker R (2004) Clinical uses of fibrin sealant. In: Mintz PD et al (eds) Transfusion therapy: clinical principles and practice, 2nd edn. AABB Press, Bethesda, MD, pp 437–477Google Scholar
- 5.Cronkite EP, Lozner EL, Deaver J (1944) Use of thrombin and fibrinogen in skin grafting. JAMA 124:976–978Google Scholar
- 6.Matras H, Dings HP, Manoli B et al (1972) Zur nachtlosen Interfaszikularen Nerventransplantation im Tierexperiment. Wein Med Wochenschr 122:517–523Google Scholar
- 7.Spotnitz WD, Welker R (1999) Clinical uses of fibrin sealant. In: Mintz PD (ed) Transfusion therapy: clinical principles and practice, 1st edn. AABB Press, Bethesda, MD, pp 199–222Google Scholar
- 13.Spotnitz WD, Burks SG, Prabhu R (2005) Fibrin-based adhesives and hemostatic agents. In: Quinn JV (ed) Tissue adhesives in clinical medicine. BC Decker, Hamilton, Ontario, Canada, pp 77–112Google Scholar