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World Journal of Surgery

, 33:111 | Cite as

Hepatic Metastasectomy for Soft-Tissue Sarcomas: Is It Justified?

  • A. Rehders
  • M. Peiper
  • N. H. Stoecklein
  • A. Alexander
  • E. Boelke
  • W. T. Knoefel
  • X. Rogiers
Article

Abstract

Background

Except for patients with gastrointestinal stromal tumors (GIST), systemic chemotherapy in patients with liver metastasis of soft-tissue sarcoma (STS) is not effective. Therefore, all patients with resectable liver metastases underwent surgical therapy. We present our experience with this approach during the last 13 years.

Methods

All patients (n = 45) with liver metastasis of STS undergoing surgical therapy were prospectively analyzed. Clinical and histopathological parameters as well as the postoperative course were recorded. Survival data were analyzed by using the Kaplan-Meier method and the log-rank test.

Results

Twenty-seven of 45 patients with liver metastasis underwent hepatic resection; 59% of these patients had a solitary metastasis, 22% had two metastases, and 18% had three or more metastatic nodules. The surgical perioperative mortality was 7%. The median survival was 44 (range, 1–123) months, and the 5-year survival was 49%. Repeated resection for recurrent tumor was performed in eight patients, which yielded a median survival of 76 months.

Conclusions

Patients who have hepatic metastases that are functionally and technically resectable should be considered for surgery because this treatment offers the chance for long-term survival (>5 years).

Keywords

Hepatic Resection Hepatic Metastasis Portal Vein Embolization Malignant Peripheral Nerve Sheath Tumor Primary Tumor Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Société Internationale de Chirurgie 2008

Authors and Affiliations

  • A. Rehders
    • 1
  • M. Peiper
    • 1
  • N. H. Stoecklein
    • 1
  • A. Alexander
    • 1
  • E. Boelke
    • 2
  • W. T. Knoefel
    • 1
  • X. Rogiers
    • 3
  1. 1.Klinik für Allgemein-, Viszeral- und KinderchirurgieUniversitätsklinikum der Heinrich-Heine-Universität DüsseldorfDüsseldorfGermany
  2. 2.Klinik für Strahlentherapie und RadioonkologieUniversitätsklinikum Düsseldorf Düsseldorf Germany
  3. 3.Klinik für Hepatobiliäre- und TransplantationschirurgieUniversitätsklinikum Hamburg-Eppendorf Hamburg Germany

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