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World Journal of Surgery

, Volume 32, Issue 10, pp 2246–2252 | Cite as

Prognostic Factors for Primary Duodenal Adenocarcinoma

  • Hyung Geun Lee
  • Dong Do You
  • Kwang Yeol Paik
  • Jin Seok Heo
  • Seong Ho Choi
  • Dong Wook Choi
Article

Abstract

Background

The aim of this study was to review the clinical features of primary duodenal adenocarcinoma (PDA) patients and to identify factors that influence survival. The natural history of PDA and the factors that affect patient outcome remain poorly defined.

Methods

The authors reviewed the medical records of 53 patients treated for PDA from January 1995 to May 2007.

Results

Altogether, 28 of the 53 patients (resectability 52.8%) underwent curative resection and 25 (47.2%) surgical palliation (bypass surgery or biopsy). Overall, the 3- and 5-year survival rates were 34.4% and 28.6%, respectively. Survival was significantly higher for patients who underwent curative resection (median survival 39 months; 3- and 5-year survivals 52.9% and 44.1%, respectively) than for those who underwent palliative surgery (median survival 8 months; 3-year survival 0%) (p < 0.001). T stage (p = 0.032) and nodal metastasis (p = 0.002) had significant negative effects on the survival of patients who underwent curative resection according to univariate analysis. However, multivariate analysis revealed that only nodal metastasis (p = 0.015) was significantly associated with survival.

Conclusions

The resectability of PDA was associated with increased survival, and metastasis to lymph nodes was found to be associated with reduced survival of patients with PDA. Findings indicate that an aggressive surgical approach should be pursued.

Keywords

Curative Resection Total Pancreatectomy Duodenal Cancer Fourth Portion Paraaortic Lymph Node Dissection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Société Internationale de Chirurgie 2008

Authors and Affiliations

  • Hyung Geun Lee
    • 1
  • Dong Do You
    • 1
  • Kwang Yeol Paik
    • 1
  • Jin Seok Heo
    • 1
  • Seong Ho Choi
    • 1
  • Dong Wook Choi
    • 1
  1. 1.Department of SurgerySamsung Medical CenterSeoulSouth Korea

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