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World Journal of Surgery

, Volume 32, Issue 8, pp 1663–1668 | Cite as

Solitary Fibrous Tumor of the Pleura: An Analysis of 13 Cases

  • Chunlai Lu
  • Yuan Ji
  • Fei Shan
  • Weigang Guo
  • Jianyong Ding
  • Di Ge
Article

Abstract

Background

Solitary fibrous tumor of the pleura is a rare soft-tissue tumor. In search of appropriate diagnosis and treatment methods, we present our experience with 13 patients.

Methods

The medical charts of 13 patients treated during the last 5 years were reviewed, as well as pathological records, including immunohistochemical stains. Follow-up data were obtained. In addition, a literature review with regard to treatment and clinical outcome was performed.

Results

Our series consisted of four men and nine women with a mean age of 47 years. Two were diagnosed before operation with ultrasonography-guided core needle biopsy. All patients underwent primary surgical treatment, and four of them were resected by video-assisted thoracic surgery. Seven tumors were malignant and the other six were benign. Immunohistochemical staining showed nestin was positive in three malignant solitary fibrous tumors of pleura (3/7), which were negative for CD34. Except for one, all patients were followed-up for 3 to 35 (mean, 14.5) months. Among them, one patient experienced a recurrence and one patient died of brain metastasis.

Conclusion

Ultrasonography-guided core needle biopsy combined with immunohistochemical analysis might be a safe and rapid method to provide a confirmatory diagnosis before resection. For smaller, pedunculated tumors, video-assisted thoracic surgery could be a powerful and useful approach. We speculate that CD34-negative and nestin-positive might be a malignant marker for solitary fibrous tumor of pleura.

Keywords

Brain Metastasis Solitary Fibrous Tumor Pedunculate Tumor Malignant Solitary Fibrous Tumor Hospital Stay Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors thank Dr. Xiaofang Yu and Dr. Huanghe Song for assistance.

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Copyright information

© Société Internationale de Chirurgie 2008

Authors and Affiliations

  • Chunlai Lu
    • 1
  • Yuan Ji
    • 2
  • Fei Shan
    • 3
  • Weigang Guo
    • 1
  • Jianyong Ding
    • 1
  • Di Ge
    • 1
  1. 1.Department of Thoracic SurgeryZhongshan Hospital, Fudan UniversityShanghaiChina
  2. 2.Department of PathologyZhongshan Hospital, Fudan UniversityShanghaiChina
  3. 3.Department of RadiologyZhongshan Hospital, Fudan UniversityShanghaiChina

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