World Journal of Surgery

, Volume 32, Issue 7, pp 1325–1332 | Cite as

What is the Evidence for Endoscopic Thyroidectomy in the Management of Benign Thyroid Disease?

Open Access
Article

Abstract

Background

Endoscopic thyroidectomy (ET) is a demanding surgical technique in which dissection of the gland is entirely performed with an endoscope, in a closed area maintained by insufflation or mechanical retraction. ET by direct cervical approach (anterior or lateral) is minimally invasive, but ET using an extracervical access (chest wall, breast, or axillary) is not. No technique seems to be universally accepted yet. This review was designed to clarify the existing evidence for performing endoscopic thyroid resections in the management of benign thyroid nodules.

Methods

A database search was conducted in PubMed and Embase from which summaries and abstracts were screened for relevant data, matching our definition. Publications were further assessed and assigned their respective levels of evidence. Additional data derived from our own unit’s experience with endoscopic thyroidectomy were included.

Results

Thirty mainly retrospective cohort studies have been published in which morbidity, such as unilateral vocal cord palsy, is poorly evaluated. ET takes from 90 to 280 minutes for lobectomy by cervical access and total thyroidectomy by chest wall approach, respectively. Cosmetic outcome in extracervical approach is less troubled by size of the resected specimen compared with direct cervical approach. Extracervical approach avoids a neck scar but implies invasiveness in terms of dissection and postoperative discomfort. Long-term cosmetic outcome comparisons with conventional thyroidectomy have not been published.

Conclusions

Currently it is not possible to recommend the application of ET based on evidence. Reported complications stress the importance of advanced endoscopic skills. ET should only be offered to carefully selected patients and, therefore, a high volume of patients requiring thyroid surgery is needed. Superiority of endoscopic to conventional thyroidectomy has yet to be demonstrated. Possible advantages of endoscopic thyroid techniques and our patient’s desire for the highest cosmetic outcome possible justify further development of ET in expert hands of endocrine surgeons.

Introduction

Since its introduction in 1996, endoscopic thyroidectomy (ET) has yet to become a standard procedure. From the start, technical issues slowed down widespread application, and ET still is a demanding and technically challenging procedure. Certainly surgeons hesitate to implement a new technique as long as the “cost/benefit” ratio remains questionable.

No clear definition exists for ET. During the last 10 years, the use of an endoscope has been reported in several techniques of thyroidectomy. In some of these techniques, the endoscope is used during just one step of the procedure. Other steps are performed as in open techniques, by direct vision, through a mini-cervical incision. Video-assisted thyroidectomy may be a more appropriate name for these semi-open techniques. We defined ET as a surgical technique in which dissection of the gland is entirely performed with the help of an endoscope, in a closed area maintained by insufflation or mechanical retraction [1]. Semi-open procedures or partially endoscopic procedures, e.g. the video-assisted cervical approach, are consequently not evaluated in this article.

ET techniques can be subdivided into cervical or direct approaches and extracervical or indirect approaches. Generally endoscopic techniques are introduced because of their minimal invasiveness, expected to result in quicker convalescence and better cosmesis compared with traditional Kocher cervicotomy. ET by direct cervical approach is definitely minimally invasive; however, this is not true for other ET using an extracervical access. In these techniques, skin incisions for trocars and extraction of the specimen are made away from the neck, avoiding any scars in the neck, but widely extending the dissection area. To evaluate its current position, we have performed a review of published data on ET.

Materials and methods

A database search was conducted in PubMed and Embase (132 hits) using (Mesh-) terms “Endoscopy AND Thyroid Gland” (90 hits) “Endoscopy AND thyroid nodule/surgery” (15 hits) “laparoscopic thyroid surgery” (13 hits), without language restrictions. Summaries and abstracts of each identified publication were screened for relevant data on ET in humans. Only publications that fulfilled the inclusion criteria were further assessed and assigned their respective levels of evidence based on Sackett’s classification system as modified by Heinrich [2] (Table 1). Techniques for ET are described hereafter.
Table 1

Sackett’s classification of level of evidence

Level

Type of trial

Criteria for classification

I

Large, randomized trials with clear-cut results

Sample size calculation, study end point

II

Small, randomized trials

Matched analysis

III

Nonrandomized, contemporaneous controls

Noncomparative, prospective

IV

Nonrandomized, historical controls

Retrospective analysis, cohort studies

V

No control, case series only, opinion of experts

Small series, review articles

The anterior cervical approach, first described by Gagner et al. [3], uses a midline access and permits bilateral dissection of the thyroid. A 5-mm optical trocar is inserted just above the suprasternal notch. Carbondioxide is insufflated with a pressure of 10 mmHg. Three additional trocars are used: two 2-mm trocars, and one 5-mm at the superior medial border of the sternocleidomastoid muscle (Fig. 1). Using ultracision, all vital structures are identified and dissected as in a conventional procedure. The piece is extracted in a plastic bag through the superolateral trocar.
Fig. 1

Anterior direct approach by Gagner

An alternative way to perform ET by anterior approach has been proposed by Cougard et al. (Fig. 2). Starting with a 15-mm median incision above the suprasternal notch, a 5-mm optical trocar is inserted, with 8 mmHg CO2 insufflation. Along the line of a virtual cervicotomy two other trocars are introduced: 3-mm trocar on the side of the operator/lesion, and 5-mm trocar at the other end. A Veress needle is added in the upper midline to improve working space only if necessary [4]. The gland is extracted through the 15-mm median incision, leaving a central neck scar along the line of virtual cervicotomy.
Fig. 2

Anterior direct approach by Cougard

The lateral cervical approach, described by Henry [1,5,7], uses the plane between the carotid sheath laterally and the strap muscles medially. This “back door” route can only be used for unilateral lesions. The procedure is performed via a 10-mm optic port and two 3-mm operating ports, placed on the medial border of the sternocleidomastoid muscle on the side of the lesion. This approach allows direct access to the posterior aspect of the thyroid lobe, without the need for the dissection of the strap muscles. The initial skin incision for the 10-mm port is placed such that in the event of conversion it can be extended medially to result in a symmetric collar incision (Fig. 3). Low-pressure (8 mmHg) insufflation with CO2 maintains the space. Once the lobe is entirely freed, the specimen is extracted through the 12–15-mm incision for division of the isthmus. Granda la Torre et al. [6] describe the use of a balloon dilator for creating the working space instead of blunt dissection.
Fig. 3

Lateral direct approach by Henry

Another lateral approach has been described by Inabnet et al. [8]. The surgery begins with a 10–15-mm incision at the superior lateral area of the neck. Once sufficient working space is created, three additional trocars (two 3 mm and one 5 mm) are inserted under direct vision (Fig. 4). The specimen is extracted in a retrieval bag through the 1-cm superolateral incision.
Fig. 4

Lateral direct approach by Inabnet

The chest wall approach is an extra cervical approach favoured for bilateral thyroid dissection. A 30-mm skin incision is made below the inferior border of the clavicle on the side of the lesion, retracting the upper border of the pectoralis major muscle manually. A 12-mm trocar is introduced for a flexible laparoscope. CO2 is insufflated to a pressure of 4 mmHg. Alternatively, cutaneous lifting devices are available [911]. One 5-mm trocar is inserted inferior to the sternal notch, and one 5-mm trocar below the ipsilateral clavicle (Fig. 5). Dissection of the gland is performed with ultracision. The specimen is retrieved in a bag through the 3-cm subclavicular incision, leaving no scar in the neck.
Fig. 5

Indirect chest wall approach

The breast approach allows bilateral dissection. On both upper circumareolar areas a trocar is inserted (two 10-mm ports, or one 12-mm and one 15-mm port) after blunt dissection with the use of a Rochester clamp and vascular tunneler or Dingmann dissector. The working space is established with CO2 insufflation at a pressure of 4–6 mmHg. The third port (5 mm) can be inserted 3 cm below the clavicle on the side of the thyroid mass or parasternal at the level of the nipple or in the axilla as shown in Fig. 6 [12, 13, 14]. Ipsilateral strap muscles are split longitudinally to elevate the thyroid and achieve good exposure of the gland. A bilateral axillo-breast approach has been developed to obtain optimal visualization of both lobes especially for total thyroidectomy in which the third and fourth port are inserted in left and right axilla [15]. The specimen is retrieved through the 12-mm breast ports. Depending on port placement, there are scars parasternal, perimammillary, and/or axillary.
Fig. 6

Indirect breast approach

The axillary approach can be used for large thyroid lesion but do not extend contralaterally. The patient is in supine position, and the ipsilateral arm on the side of the lesion placed at a 90° angle to the axis of the body. Three 5-mm incisions are placed below the anterior axillary line equidistant apart or one 30-mm incision is made for a 12-mm and 5-mm trocar, apart from the third trocar (5 mm) (Fig. 7). A 5-mm 0° optical scope or flexible laparoscope with CO2 insufflation at 4–9 mmHg pressure is introduced before starting sharp scissor dissection to dissect an avascular plane between platysma and pectoralis major muscle. A gasless axillary approach is feasible if an external lifting device is applied [16]. Next, the plane between SCM and sternohyoid muscle is developed to elevate the sternothyroid muscle and allow retraction anteriorly, exposing the ipsilateral thyroid gland. Harmonic scalpel and clips are used for division. A retrieval bag is used for extraction of the gland through the axilla [17, 18, 19, 20, 21]. All incisions are hidden in the axillary fossa.
Fig. 7

Indirect axillary approach

Results

To our knowledge, data providing Level I evidence (prospective and randomized studies) for ET have not yet been published. Mainly retrospective cohort studies have been published (Table 2). Because of the many possible small differences in approach and poor number of patients or studies published more than once, no meta-analysis can be performed.
Table 2

Published studies on endoscopic thyroidectomy

Study

n

Level

Approach

Gagner et al. [3]

18

III

Anterior cervical

Cougard et al. [4]

40

III

Anterior cervical

Yeung [22]

18

IV

Anterior cervical

Casanova [23]

1

V

Anterior cervical

Palazzo et al. [5]

38

IV

Lateral cervical

Sebag et al. [7]

38

IV

Lateral cervical

Henry and Sebag [1]

38

IV

Lateral cervical

Inabnet et al. [8]

38

III

Lateral cervical

Kitano et al. [9]

20

IV

Chest wall

Usui et al. [11]

19

IV

Chest wall

Kim et al. [24]

35

IV

Chest wall

Shimizu and Tanaka [10]

193

III-IV

Chest wall

Park et al. [13]

100

IV

Breast

Choe et al. [15]

135

III-IV

Breast

Ohgami et al. [12]

5

IV

Breast

Shimazu et al. [14]

12

III

Breast

Yamamoto et al. [25]

12

IV

Breast

Yamamoto et al. [26]

10

III

Breast

Ishii et al. [27]

5

IV

Breast

Wang et al. [28]

150

IV

Breast

Ikeda et al. [19]

15

II-III

Axillary and chest wall

Takami and Ikeda [29]

27

IV-V

Axillary

Takami and Ikeda [30]

36 and 22

IV

Axillary and chest wall

Ikeda et al. [17]

1

V

Axillary

Duncan et al. [21]

32

IV

Axillary

Ikeda et al. [18]

19

IV

Axillary

Ikeda et al. [31]

20

III

Axillary

Yoon et al. [16]

30

IV

Axillary

Chantawibul et al. [32]

20

IV

Axillary

Ikeda et al. [20]

20

IV

Axillary

Anterior cervical approach

Gagner et al. [3] presents the results of 18 ET by anterior cervical approach for solitary nodules compared with 18 consecutive classical cervicotomies. Feasibility and safety are confirmed. Aesthetic results are superior and convalescence is reduced compared with classical cervicotomy. Cougard et al. [4] present results of prospectively gathered data on 40 patients demonstrating its feasibility. The use of ultrasonic shears diminished the conversion rate.

Lateral cervical approach

Henry and Sebag [1], Palazzo et al. [5], and Sebag et al. [7], describe the technique of ET via lateral approach (3 trocars) performed in 38 patients, as developed for parathyroidectomy. The number accounts for approximately 5.1% of all thyroidectomies performed per year (2004). If frozen-section or definitive histology revealed malignancy that necessitated complete thyroidectomy, it was performed via conventional cervicotomy. Between 2004 and 2007, 112 ETs were performed in our institution. Five procedures were converted and five cases required open completion thyroidectomy for diagnosis of cancer. This experience has lead to a mean operative time of 98 (range, 46–190) minutes. Morbidity rate includes one definitive recurrent nerve palsy and one hematoma, which did not necessitate reoperation.

Inabnet et al. [8] reports three conversions due to insufficient working space in a series of 38 patients.

Chest wall approach

Kitano et al. [9] and Takami and Ikeda [29, 30] present retrospective cohort studies of chest wall (20 and 22 patients respectively) and axillary approach (63 patients). Microcarcinomas and bilateral multinodular goiter are included, and according to these authors prophylactic dissection of ipsilateral pre- and para-tracheal nodes seems feasible. Postoperative pain and paraesthesias disappear within 3 months.

Ikeda et al. [19] performed one study that compared conventional, anterior chest, and axillary approaches; each group had 15 patients in which the procedure was selected by turns. Three months postoperatively, the incidence of swallowing discomfort was higher in the open surgery group than in endoscopic surgery group. The axillary approach rendered highest cosmetic results according to patients’ questionnaires.

Kim et al. [24] and Shimizu and Tanaka [10] used a gasless retractor system (anterior neck-skin lifting) to minimize possible complications of gas-insufflating surgery. The latter reviews 193 cases and compares them with 20 consecutive conventional cervicotomies. Four of 193 (2.1%) cases of temporal recurrent nerve paralysis, probably the result of thermal injury, are reported. The operative time and amount of bleeding significantly reduced as the surgeon gained experience with the technique.

Breast approach

Park et al. [13] share their experience in 100 patients operated via breast approach. Six cases were converted to conventional procedures: five because of malignancy on frozen-section, and one because of uncontrolled bleeding/technical failure. One case of permanent recurrent laryngeal nerve palsy probably caused by thermal injury with ultrasonic scalpel is mentioned, but it is unclear whether all vocal cords were checked postoperatively. Choe et al. [15] presents a 135-patients’ retrospective cohort operated by bilateral axillo-breast approach. One procedure was complicated by postoperative infection after primary repair of esophageal injury and one by pneumothorax. Yamamoto et al. [25] reported the feasibility of breast approach for treating patients with Graves’ disease by subtotal thyroidectomy. In a small, prospective study [26], 12 conventional thyroidectomies are compared with 10 endoscopic breast procedures. Blood loss was significantly less in the endoscopic group. Convalescence time or any other parameters were not significantly different. The study by Wang et al. [28], on 150 patients treated via the breast approach without any complications occurring and six conversions, could not be retrieved apart from abstract data.

Axillary approach

Ikeda et al. [19, 20, 31] have published three matched analysis studying the axillary approach. One procedure was complicated by hemorrhage of sternocleidomastoid muscle, which necessitated conversion to open surgery, and one patient had subcutaneous cervical emphysema, which resolved postoperatively. A comparative study of axillary, chest wall, and conventional approach (15 cases per group, selection by turns) revealed excellent cosmetic results in patients treated using the axillary approach, which took the longest operative time (average 175 minutes vs. 145 in chest wall and 84 minutes in open surgery) [19]. Swallowing discomfort was higher in the open surgery group. In comparing 3-cm video-assisted approach, the axillary technique (20 consecutive patients) was significantly more painful [31]. In a retrospective analysis (20 patients per group) operative time for conventional surgery seems significantly shorter, but postoperative paint did not seem to differ between axillary and conventional approach except on the first postoperative day on which the axillary technique is more painful [20].

Duncan et al. [21] published their retrospective results of 32 cases operated for solitary nodules limited to one lobe. Pain and discomfort caused by this approach are noted to subside within 1 week generally, resulting in return to daily activity on day 6.2 after surgery.

Yoon et al. [16] used an external retractor inserted through a 35-mm axillary skin incision and reported a retrospective cohort of 30 patients. Operative time was increased with the size of resected nodule. One minor tracheal injury without air leakage occurred. Patient characteristics and study data are shown in Table 3.
Table 3

Patient characteristics and operative data

Study

Approach

Male: female ratio

Age (yr)

Nodule size (mm)

Operating time (min)

Conversion

Complication rate

Nerve palsy

Discharge (day)

Palazzo et al. [5]

Lateral cervical

5:33

45

22

99

5/38

 

0

1

Sebag et al. [7]

Lateral cervical

 

45

19,2

102

4/38

 

0

1

Inabnet et al. [8]

Lateral cervical

  

25

190

3/38

 

1

 

Gagner et al. [3]

Ant. Cervical

2:16

43

27

220

2/18

3 hypercapnia

0

1

Cougard et al. [4]

Ant. Cervical

4:36

46

24

89

8/24 0/16c

 

0

1

Yeung et al. [22, 34]

Ant. Cervical

 

42

25

185

4/18

none

  

Kitano et al. [9]

Chest wall

1:19

44

30

279

0

1 emphysema

1 temp

4

Ikeda et al. [19]

Chest wall

1:14

40

40

145

0

 

0

4

Takami and Ikeda [30]

Chest wall

 

41

<54

157

1/58

1 emphysema

0

 

Usui et al. [11]

Chest wall

  

35

148

0

 

0

 

Kim et al. [24]

Chest wall

3:32

39

30

156

3/35

 

1 temp

 

Shimizu and Tanaka [10]

Chest wall

   

120

0

3 seroma

4 temp

 

Park et al. [13]

Breast

7:93

39

26

100

  

1

 

Choe et al. [15]

Breasta

2:133

37

14

175

 

1 esophageal injury 1 pneumothorax

4 temp

 

Ohgami et al. [12]

Breast

0:5

48

 

226

    

Shimazu et al. [14]

Breast b

0:12

34

44

188

  

0

 

Shimazu et al. [14]

Breast

0:4

41

45

270

  

0

 

Yamamoto et al. [25]

Breast

4:8

28

 

260

  

1

 

Yamamoto et al. [26]

Breast

0:10

45

38

 

0

 

0

 

Ishii et al. [27]

Breast

0:5

48

 

226

    

Wang et al. [28

Breast

   

80

6/150

none

0

4

Duncan et al. [21]

Axillary

2:30

33

42

139

0

1 hematoma

2 temp

1

Takami and Ikeda [30]

Axillary

 

41

<54

172

1/58

 

0

 

Ikeda et al. [18]

Axillary

2:17

45

37

212

1/19

 

0

 

Ikeda et al. [19]

Axillary

1:14

42

42

175

0

 

0

4

Ikeda et al. [31]

Axillary

1:19

36

42

168

0

1 emphysema

0

 

Ikeda et al. [20]

Axillary

1:19

42

42

168

0

 

0

4

Takami and Ikeda [29]

Axillary

  

<55

172

1/58

1 emphysema

0

 

Yoon et al. [16]

Axillary

0:30

40

22

127

 

1 tracheal injury

0

4

Chantawibul et al. [32]

Axillary

 

37

30

175

1/45

1 seroma

1 temp

3

aBilateral axillo-breast approach

bAxillo-bilateral-breast approach

cWithout and with use of ultrasonic shears

Discussion

The principal indication for ET remains management of benign thyroid disease. ET using a cervical access is restricted to solitary nodules <3 cm in diameter and to thyroid lobes up to 20 ml in volume [1, 3, 4, 5, 7, 8, 23]. Larger cysts if preoperatively aspirated may be removed by cervical access. Generally benign nodules <3 cm do not require surgery, so only small nodules presenting with follicular cytology or small toxic adenomas are eligible. Therefore, 5–12% of patients who require surgical intervention for a thyroid nodule may be selected for ET by cervical approach [1, 3, 4]. Small goiters and limited Graves’ disease also may be a potential indication for ET, although they generally do not require surgery. Some contraindications are common to all these techniques: large goiters, invasive malignant tumors, previous cervical operations, and history of neck irradiation. Extracervical access permits larger lesions up to 60 mm in size and enlarged glands (up to 60 ml volume) to be extracted endoscopically and also low-risk carcinomas (to 10–20 mm in size; younger than aged 50 years, node-negative, intrathyroidal) have been assessed by the extracervical approach [9, 15, 16, 17, 18, 19, 21, 25, 26, 29, 30, 33]. Therefore, 34–53% may be treated by indirect ET [10, 20, 29].

ET takes from 90 minutes for lobectomy by cervical access to 280 minutes for total thyroidectomy by chest wall approach. Adjustments in operative technique and passing the learning curve reduce operative time [18]. Open superior pole division [8], the application of ultracision [4], and limiting indications to maximally 40 mm unilateral nodes [19] all substantially contribute to shortening of the operative procedure.

The need for custom-engineered skin-lifting devices instead of low-pressure gas insufflation is questionable. Fear of insufflation-related complications, such as hypercapnia, extensive emphysema, and gas embolisms, is not sustained if appropriate precautions are taken: low flow 1 l/min, insufflation pressure <10 mmHg [35, 36, 37, 38].

Morbidity should remain among the main outcome parameters. In extracervical approaches, a minor risk of subcutaneous hemorrhage without any evidence for increasing infection rates is present as a result of the extensive dissection [21]. In general, thyroid-specific complications, hypocalcemia, and vocal cord palsy have been poorly evaluated. Preoperative and postoperative laryngoscopy and serum calcium should be performed in a standardized manner to assess morbidity before making any comparison with conventional cervicotomy. Dissection under magnified endoscopic view demonstrating precise anatomic detail may likely enhance patient’s safety and contribute to a reduction of 1–3% incidence of recurrent laryngeal nerve injury [33, 40]. Until now, we have found no evidence to state that morbidity of ET is at least equal to the conventional equivalent.

The conversion rate varies from 0–13%. Peroperative reasons to convert any ET apart from histology are hemorrhage, difficulty in dissection (due to lack of working space), size of the lesion, thyroiditis, and tracheal injury. Five percent to 11% of patients operated by direct cervical or indirect breast approach will require a second operation because of definitive malignant histology, despite malignancy being a contraindication for the primary intervention [1, 3, 5, 7, 8, 13]. Reoperation was performed 1 week to 3 months after the primary operation.

Maximization of cosmetic outcome by changing access site is subject to personal opinion. A lateral approach, cervical or axillary, may be cosmetically superior. Patient’s satisfaction with the cosmetic result varies from being satisfied to being highly or extremely satisfied. However again, no studies have compared cosmetic outcomes of ET and conventional cervicotomy during longer follow-up.

Whether transection of neck musculature or asymmetry of neck musculature after cutting the omohyoid muscle in extracervical approaches, for example, affects functionality is not clear. Insufficient working space often is followed by conversion and by transection a wider working space is obtained. In axillary and chest wall approach, transection of strap muscles may only be necessary in large tumors. Postoperatively it may cause uncomfortable catching sensation on swallowing by adherence of skin or platysma to sternohyoid muscle; however, this sensation also is experienced by patients after Kocher’s cervicotomy.

After extracervical techniques, patients suffer from moderate to severe pain, which gradually subsides within 1 week. Postoperative paresthesias or numbness generally subside within 6 months. After cervical approaches patients are hospitalized for 24 hours. After axillary/chest wall approach it varies from fourth day postoperatively to seventh after breast approach, which may be because of difference in pain. Gagner [3, 33] reported a 50% reduction in convalescence time, which seems of importance. Whether costs of harmonic scalpel, surgical instruments, and longer operative time outweighs the reduction in length of hospital stay (direct approach compared with conventional surgery) and shorter convalescence time is to be investigated.

Controversy remains regarding inclusion of low-risk thyroid carcinoma. Indeed low-risk papillary carcinomas are characteristic of young women searching for a minimal scar. Potential oncologic risks, such as seeding and local recurrence, have not been properly evaluated for endoscopic thyroid surgery [18, 19, 39, 41]. Neither has endoscopic neck dissection proven to be feasible rendering exploration in search of enlarged nodes inadequate [9, 10, 15, 30]. Conversion to assess properly for the presence of lymphadenopathy is advisable.

Conclusions

The fact that many different endoscopic techniques have been described and that none seem to be universally accepted may be a direct result of technical difficulties and unproven superiority of one technique compared with another. Currently it is not possible to recommend the application of ET based on evidence. However, there exists general agreement that ET is a valid and feasible option for carefully selected patients. Reported complications stress the importance of advanced endoscopic skills and substantial experience in working in two-dimensional field; a must before starting to perform highly advanced endoscopic thyroid surgery. ET should only be offered to carefully selected patients, and therefore, a high volume of patients requiring thyroid surgery is needed. This may only be reached by centralization of thyroid surgery.

Taken together, superiority of endoscopic to conventional thyroidectomy has yet to be demonstrated. The possible advantages of endoscopic thyroid techniques and our patient’s desire for the highest cosmetic outcome justify further development of ET in expert hands of endocrine surgeons.

Notes

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Copyright information

© The Author(s) 2008

Authors and Affiliations

  1. 1.Department of Endocrine Surgery University Hospital MarseilleService de Chirurgie Générale et Endocrinienne, CHU-Hôpital de la TimoneMarseille cedex 05France

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