- 1.3k Downloads
Goiters were often associated with iodine deficiency in European mountain areas, with some goiters being quite disfiguring. However, some goiters seem not to be related to iodine deficiency. One of the types of goiter that are unrelated to iodine deficiency is the disease described by Hakaru Hashimoto in 1912. Hashimoto described it as a special characteristic of a new type of lymphomatous thyroid tumor in Japan, and this entity was recognized as an autoimmune disease of the thyroid many years later. Hashimoto published his article in a German journal because that was the scientific language of the time, and he thought that writing in German would make the work more widely available around the world. Patients with Hashimoto’s thyroiditis are usually asymptomatic, and some patients develop goiters with or without hypothyroidism. The goiters and hypothyroidism usually respond to treatment with thyroid hormone. The dose of thyroid hormone must be carefully titrated because there may be autonomous thyroid function resulting from thyroid-stimulating antibodies despite the hypothyroid state.
The authors thank Dr. Kazuo Hashimoto, Professor Emeritus, Kanazawa University, the son of Dr. Hakaru Hashimoto, for offering valuable materials.
- 1.Hahsimoto H (1912) Zur Kenntniss der lymphomatösen Vernderung der Shilddrüse (Struma lymphomatosa). Arch Llin Chir 97:219–248Google Scholar
- 3.Heineke (1914) Die chronische Thyreoiditis. Dtsch Z Chir 129:189–220Google Scholar
- 4.Reist A (1922) Über chronische Thyreoiditis. Frankf Z Pathol 28:141–200Google Scholar
- 5.Riedel BMCL (1896) Die chronische zur Bildung eisenharter Tumoren führende Entzündung der Schilddrüse. Verh Dtsch Ges Chir 25:101–105Google Scholar
- 6.Graham A (1931) Riede’s struma in contrast tostruma lymphomatosa (Hashimoto). West J Surg 39:681–689Google Scholar
- 7.Joll CA (1932) Diseases of the Thyroid Gland with Special Reference to thyrotoxicosis. William Heinemann, London, p 112Google Scholar
- 12.Grotkowski CE (1992) Thyroid aspiration cytology. In: Atkins BF, editor. Atlas of Diagnostic Cytopathology. Saunders, Philadelphia, pp 534–535Google Scholar
- 13.Ahlmann AJ, Burman KD (1987) The role of T-lymphocytes in autoimmune thyroid disease. Endocrinol Metab Clin North Am16:287–326Google Scholar
- 15.Ahuja AT (2000) The thyroid and parathyroids. In Ahuja AT, Evans RM, editors. Practical Head and Neck Ultrasound. Greenwich Medical Media, London, pp 35–64Google Scholar