World Journal of Surgery

, Volume 32, Issue 5, pp 688–692 | Cite as

Hashimoto’s Thyroiditis

  • Hiroshi E. TakamiEmail author
  • Rika Miyabe
  • Kaori Kameyama
Editorial Perspective


Goiters were often associated with iodine deficiency in European mountain areas, with some goiters being quite disfiguring. However, some goiters seem not to be related to iodine deficiency. One of the types of goiter that are unrelated to iodine deficiency is the disease described by Hakaru Hashimoto in 1912. Hashimoto described it as a special characteristic of a new type of lymphomatous thyroid tumor in Japan, and this entity was recognized as an autoimmune disease of the thyroid many years later. Hashimoto published his article in a German journal because that was the scientific language of the time, and he thought that writing in German would make the work more widely available around the world. Patients with Hashimoto’s thyroiditis are usually asymptomatic, and some patients develop goiters with or without hypothyroidism. The goiters and hypothyroidism usually respond to treatment with thyroid hormone. The dose of thyroid hormone must be carefully titrated because there may be autonomous thyroid function resulting from thyroid-stimulating antibodies despite the hypothyroid state.



The authors thank Dr. Kazuo Hashimoto, Professor Emeritus, Kanazawa University, the son of Dr. Hakaru Hashimoto, for offering valuable materials.


  1. 1.
    Hahsimoto H (1912) Zur Kenntniss der lymphomatösen Vernderung der Shilddrüse (Struma lymphomatosa). Arch Llin Chir 97:219–248Google Scholar
  2. 2.
    Simmonds M (1913) Über lympnatische Herde in der Schilddrüsse. Virchows Arch Pathol Anat Physiol 211:73–89CrossRefGoogle Scholar
  3. 3.
    Heineke (1914) Die chronische Thyreoiditis. Dtsch Z Chir 129:189–220Google Scholar
  4. 4.
    Reist A (1922) Über chronische Thyreoiditis. Frankf Z Pathol 28:141–200Google Scholar
  5. 5.
    Riedel BMCL (1896) Die chronische zur Bildung eisenharter Tumoren führende Entzündung der Schilddrüse. Verh Dtsch Ges Chir 25:101–105Google Scholar
  6. 6.
    Graham A (1931) Riede’s struma in contrast tostruma lymphomatosa (Hashimoto). West J Surg 39:681–689Google Scholar
  7. 7.
    Joll CA (1932) Diseases of the Thyroid Gland with Special Reference to thyrotoxicosis. William Heinemann, London, p 112Google Scholar
  8. 8.
    Woolner LB, McConahey WM, Beahrs OH (1959) Struma lymphomastosa (Hashimoto’s thyroiditis) and related thyroid disorders. J Endocrinol Metab 19:53–83CrossRefGoogle Scholar
  9. 9.
    Shamsuddin AKM, Lane RA (1981) Ultrastructural pathology in Hashimoto’s thyroiditis. Hum Pathol 12:561–573PubMedCrossRefGoogle Scholar
  10. 10.
    Vickery AL, Hamlin E (1961) Struma lymphomatosa (Hashimoto’s thyroiditis): observations on repeated biopsies in sixteen patients. N Engl J Med 264:226–229PubMedCrossRefGoogle Scholar
  11. 11.
    Sheu SY, Schmid KW (2003) Entzündliche Schilddrüsenerkrankungen. Pathologe 24:339–347PubMedCrossRefGoogle Scholar
  12. 12.
    Grotkowski CE (1992) Thyroid aspiration cytology. In: Atkins BF, editor. Atlas of Diagnostic Cytopathology. Saunders, Philadelphia, pp 534–535Google Scholar
  13. 13.
    Ahlmann AJ, Burman KD (1987) The role of T-lymphocytes in autoimmune thyroid disease. Endocrinol Metab Clin North Am16:287–326Google Scholar
  14. 14.
    Oertel JE, Heffess CS (1987) Lymphoma of the thyroid and related disorders. Semin Oncol 14:333–342PubMedGoogle Scholar
  15. 15.
    Ahuja AT (2000) The thyroid and parathyroids. In Ahuja AT, Evans RM, editors. Practical Head and Neck Ultrasound. Greenwich Medical Media, London, pp 35–64Google Scholar
  16. 16.
    Dayan CM, Daniels GH (1996) Chronic autoimmune thyroiditis. N Engl J Med 335:99–106PubMedCrossRefGoogle Scholar
  17. 17.
    Hegedus L, Hansen JM, Feldt-Rasmmsen U (1991) Influence of thyroxine treatment on thyroid size and antithyroid peroxidase antibodies in Hashimoto’s thyroiditis. Clin Endocrinol (Oxf) 35:235–241CrossRefGoogle Scholar

Copyright information

© Société Internationale de Chirurgie 2008

Authors and Affiliations

  • Hiroshi E. Takami
    • 1
    Email author
  • Rika Miyabe
    • 1
  • Kaori Kameyama
    • 2
  1. 1.Department of SurgeryTeikyo University School of MedicineTokyoJapan
  2. 2.Department of PathologyKeio University School of MedicineTokyoJapan

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