World Journal of Surgery

, Volume 31, Issue 4, pp 624–631

Nitric Oxide Accelerates the Recovery from Burn Wounds


DOI: 10.1007/s00268-007-0727-3

Cite this article as:
Zhu, H., Ka, B. & Murad, F. World J. Surg. (2007) 31: 624. doi:10.1007/s00268-007-0727-3


A full-thickness burn wound model was used to evaluate the effects of a topically applied gel-based nitric oxide donor on wound healing in rats. The histological study demonstrated that the nitric oxide (NO) application significantly promoted re-epithelization that resulted in a fast recovery of burn wound. The histological sections further revealed that inflammatory cell infiltration in the NO-treated group was significantly increased in comparison to the control group. The enhanced accumulation of inflammatory cells resulted in a higher expression of myeloperoxidase (MPO) that was detected with imunoblotting. An immunohistochemistry study with CD31, a specific marker for endothelial cells, indicated that NO treatment markedly stimulated angiogenesis. Evaluation of collagen synthesis by immunohistochemistry with procollagen antibody demonstrated a significantly increased collagen synthesis in NO-treated wound bed. We concluded that NO treatment promoted re-epithelialization and wound closure by means of enhanced inflammatory cell infiltration, and that it promoted angiogenesis and facilitated collagen synthesis in the wound bed.

Copyright information

© Société Internationale de Chirurgie 2007

Authors and Affiliations

  1. 1.Department of Integrative Biology and PharmacologyInstitute of Molecular Medicine, The University of Texas–Health Science Center at HoustonHoustonUSA

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