World Journal of Surgery

, Volume 31, Issue 4, pp 795–801 | Cite as

Outcomes of Hepatic Resection for a Single Large Hepatocellular Carcinoma

  • Yong Beom Cho
  • Kuhn Uk Lee
  • Hae Won Lee
  • Eung-Ho Cho
  • Sung-Hoon Yang
  • Jai Young Cho
  • Nam-Joon Yi
  • Kyung-Suk Suh



The proper role of surgical resection, given the various treatment modalities available, needs to be further clarified in patients with a single large hepatocellular carcinoma (HCC). To evaluate the role of surgical resection in this group of patients, we studied the long-term outcomes of patients that received hepatic resection for a single large (> 5–10 cm in diameter) HCC.


The clinicopathologic data and long-term outcomes of 61 patients with a single large HCC (> 5–10 cm in diameter; L group) were compared with those of 169 patients with a single small HCC (≤ 5 cm; S group). Prognostic factors were evaluated by univariate and multivariate analysis.


Operative mortality rates were low in both groups (0.6% in group S and 1.6% in group L), and the incidence of postoperative hepatic failure was rare even in group L (1.6%). The cumulative 5-year overall survival rate in group S was 59.0%, whereas in group L it was 52.9% (p = 0.385), and the corresponding cumulative 5-year disease-free survival rates were 44.1% and 31.7%, respectively (p = 0.063). Child class B was found to predict poor overall and disease-free survival by multivariate analysis versus Child class A in both groups. The presence of microvascular invasion was also identified as a significant prognostic factor, but it only affected disease-free survival in the two groups.


Single large HCCs do not require a large extent of hepatic resection and the associated increased risk of postoperative liver failure. The long-term survival of patients with a single large HCC is as good as that of patients with a single small HCC. We conclude that hepatic resection is a safe and effective therapy for single large HCCs.


Tace Hepatic Resection Barcelona Clinic Liver Cancer Microvascular Invasion Postoperative Liver Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Société Internationale de Chirurgie 2007

Authors and Affiliations

  • Yong Beom Cho
    • 1
  • Kuhn Uk Lee
    • 1
  • Hae Won Lee
    • 1
  • Eung-Ho Cho
    • 1
  • Sung-Hoon Yang
    • 1
  • Jai Young Cho
    • 1
  • Nam-Joon Yi
    • 1
  • Kyung-Suk Suh
    • 1
  1. 1.Department of SurgerySeoul National University College of MedicineSeoulSouth Korea

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