Meta-analyses in Cancer Clinical Trials: Principles and Pitfalls

Glass GV. Primary, secondary, meta-analysis of research. Educat Res1976;5:3–8CrossRefGoogle Scholar

Pocock SJ, Lagakos SW. Practical experience of randomization in cancer trials: an international survey. Br J Cancer 1982;46:368PubMedGoogle Scholar

Sacks HS, Barrier J, Reitman D, et al. Meta-analyses of randomized controlled trials. N Engl J Med 1987;316:450PubMedCrossRefGoogle Scholar

Yates F, Cochran WG. The analysis of groups of patients. J R Stat Soc 1937;4:102–118Google Scholar

Chalmers TC, Matta RJ, Smith H, et al. Evidence favouring the use of anticoagulants in the hospital phase of acute myocardial infarction. N Engl J Med 1977;297:1091–1096PubMedCrossRefGoogle Scholar

Fibrinolytic Therapy Trialists Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction. Lancet 1994;343:311Google Scholar

ISIS-1 (First International Study of Infarct Survival) Collaborative Group. A randomized trial of intravenous atenolol amongst 16,027 cases of suspected acute myocardial infarction: ISIS-1. Lancet 1986;2:57–66Google Scholar

Peto R. Why do we need systematic overviews of randomized trials? Stat Med 1987;6:233–240PubMedGoogle Scholar

Hennekens CH, Buring JE, Hebert PR. Implications of overviews of randomized trials. Stat Med 1987;6:397–402PubMedGoogle Scholar

Chalmers TC, Leven H, Sacks HS, et al. Meta-analysis of clinical trials as a scientific discipline. I: control of bias and comparison with large co-operative trials. Stat Med 1987;6:315PubMedGoogle Scholar

Peto R, Collins R, Gray R. Large-scale randomized evidence: large, simple trials and overviews of trials. Ann NY Acad Sci 1994;703:314Google Scholar

Kassirer JP. Clinical trials and meta-analysis. N Engl J Med 1992;327:273–274PubMedCrossRefGoogle Scholar

Green S, Benedetti J, Crowley J. Clinical Trials in Oncology, Chapter 9, London, Chapman and Hall, 1997;167–182Google Scholar

Furberg CD, Morgan TM. Lessons from overviews of cardiovascular trials. Stat Med 1987;6:295PubMedGoogle Scholar

Collins R. Discussion. Stat Med 1987;6:338Google Scholar

Tobias J, Houghton J, Riley DL. Moving the Goalposts–a review of clinical trial strategies in early breast cancer. In Breast Cancer–New Horizons in Research and Treatment, Chapter 17, London, Arnold, 2001;195–202Google Scholar

Early Breast Cancer Trialists Collaborative Group. Treatment of early breast cancer. Vol I: Worldwide Evidence, 1985–1990, Oxford and New York, Oxford University Press, 1990Google Scholar

Early Breast Cancer Trialists’ Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic or immune therapy: 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Lancet 1992;339:1–15, 71–85Google Scholar

Begg CB. A measure to aid in the interpretation of publicized clinical trials. Stat Med 1985;4:1PubMedGoogle Scholar

Collins R, Gray R, Godwin J, et al. Avoidance of large biases and large random errors in assessment of moderate treatment effects: the need for systematic overviews. Stat Med 1987;2:245Google Scholar

Gelber RD, Goldhirsch A. The concept of an overview of cancer clinical trials with special emphasis on early breast cancer. J Clin Oncol 1986;4:1696–1703PubMedGoogle Scholar

Demets D. Methods for combining randomized clinical trials: strengths and limitations. Stat Med 1987;6:341–348PubMedGoogle Scholar

Simon R. The role of overviews in cancer therapeutics. Stat Med 1987;6:389–393PubMedGoogle Scholar

Simes RJ. Publication bias: the case for an international registry of clinical trials. J Clin Oncol 1986;4:1529PubMedGoogle Scholar

Tippett LHC. The Method of Statistics, London, Williams and Norgate, 1931Google Scholar

Fisher RA. Statistical Methods for Research Workers, 4th edn, London, Oliver and Boyd, 1932Google Scholar

Pearson K. On a method of determining whether a sample of given size n supposed to have been drawn from a parent population having a known probability integral has probably been drawn at random. Biometrika 1933;25:379CrossRefGoogle Scholar

Fisher RA. Combining independent test of significance. Am Stat 1948;2:30CrossRefGoogle Scholar

Dersimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177PubMedCrossRefGoogle Scholar

May GS, Eberlein K, Furberg G, et al. Secondary prevention trials after myocardial infarction: a review. Prog Cardiovasc Dis 1982;24:331–352PubMedCrossRefGoogle Scholar

Yusuf S, Peto R, Lewis J. et al. Beta-blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985;27:335–371PubMedGoogle Scholar

Yusuf S, Collins R, Peto R, et al. Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: overview of results on mortality, reinfarction and side-effects from 33 randomised controlled trials. Eur Heart J 1985;6:556–585PubMedGoogle Scholar

The 2000 EBCTCG overview: a widening gap. Comment. Lancet 2005;365:1665–1666Google Scholar

Wittes RE. Problems in the medical interpretation of overviews. Stat Med 1987;6:269PubMedGoogle Scholar

Berlin JA, Laird NM, Sacks HS, et al. A comparison of statistical methods for combining event rates from clinical trials. Stat Med 1989;8:141PubMedGoogle Scholar

Lau J, Antman EM, Jimenez-Silva J, et al. Cumulative meta-analysis of therapeutic trials for myocardial infarction. JAMA 1992;268:240–248PubMedCrossRefGoogle Scholar

Early Breast Cancer Trialists Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15 year survival: an overview of the randomized trials. Lancet 2005;365:1687–1717CrossRefGoogle Scholar