World Journal of Surgery

, Volume 29, Issue 3, pp 271–275 | Cite as

Roles of Neuropilins in Neuronal Development, Angiogenesis, and Cancers

  • Changyi ChenEmail author
  • Min Li
  • Hong Chai
  • Hui Yang
  • William E. Fisher
  • Qizhi Yao


Neuropilin-1 (NRP1) and neuropilin-2 (NRP2) are transmembrane glycoproteins that have been characterized as receptors for both semaphorins for neuronal guidance and vascular endothelial growth factor (VEGF) for angiogenesis. Biologic properties of NRPs have been linked to their unique domain structures. However, molecular interaction among NRPs, VEGF, and VEGF receptors is still not clear. Although several types of cancer cells can express NRPs, the role of NRPs in tumor pathogenesis is largely unknown. Thus, future investigations should include determining the effects and mechanisms of NRPs on proliferation, apoptosis, and migration of neuronal , endothelial, and cancer cells. Study of protein-protein interaction, signal transduction pathways, and NRP-mediated gene expression is particularly important to understand NRPs functions, which may have significant clinical applications in the treatment of neurological disorders, cardiovascular diseases, and certain cancers.


Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor Receptor Vascular Endothelial Growth Factor Protein Endocrine Pancreatic Tumor Vascular Endothelial Growth Factor Family 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by National Institutes of Health Grants R01 HL61943 (C.C), R01 HL60135 (C.C), R01 HL65916 (C.C.), Methodist 39935 (M.L.), R01 HL72716 (C.C.), K08 CA85822 (W.F.), R13 CA101889 (F.C.B.), R21 AI 49116 (Q.Y.), and R01 DE015543 (Q.Y.).


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Copyright information

© Société Internationale de Chirurgie 2005

Authors and Affiliations

  • Changyi Chen
    • 1
    Email author
  • Min Li
    • 1
  • Hong Chai
    • 1
  • Hui Yang
    • 1
  • William E. Fisher
    • 1
  • Qizhi Yao
    • 1
  1. 1.Molecular Surgeon Research Center, Michael E. DeBakey Department of SurgeryBaylor College of Medicine and the Methodist HospitalHoustonUSA

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