World Journal of Surgery

, Volume 29, Issue 3, pp 276–280 | Cite as

Roles of Cyclophilins in Cancers and Other Organ Systems

  • Qizhi Yao
  • Min Li
  • Hui Yang
  • Hong Chai
  • William Fisher
  • Changyi Chen


Cyclophilins are originally identified as cellular binding proteins for the immunosuppressive drug cyclosporin A. Many cyclophilins, including CypA, CypB, CypC, CypD, and Cyp40, have been discovered and shown to be ubiquitously distributed in many types of cells and organ systems. Recent investigations have uncovered many important properties and functions for cyclophilins including peptidyle-prolyl-isomerase activity and protein folding/repair; maintaining mitochondrial functions and involvement in apoptosis; roles in regulation of T-cell function and inflammation; interaction with CD147; and pathogenesis of vascular disease, human immunodeficiency virus infection, and rheumatoid arthritis. Furthermore, the expression and functions of cyclophilins may be correlated with tumor biology of several types of cancers including pancreatic carcinoma. Molecular mechanisms of cyclophilin-mediated biologic events and future directions of research are discussed in this review. Understanding the roles of cyclophilins in cancers and other organ systems will be crucial in determining clinical applications for the treatment or diagnosis of human diseases.


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Copyright information

© Société Internationale de Chirurgie 2005

Authors and Affiliations

  • Qizhi Yao
    • 1
  • Min Li
    • 1
  • Hui Yang
    • 1
  • Hong Chai
    • 1
  • William Fisher
    • 1
  • Changyi Chen
    • 1
  1. 1.Molecular Surgeon Research Center, Michael E. DeBakey Department of SurgeryBaylor College of Medicine and The Methodist HospitalHoustonUSA

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