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World Journal of Surgery

, Volume 29, Issue 4, pp 524–527 | Cite as

Hepatic Resection for Metastatic Breast Cancer: Prognostic Analysis of 34 Patients

  • Yoshihiro Sakamoto
  • Junji Yamamoto
  • Masataka Yoshimoto
  • Fujio Kasumi
  • Tomoo Kosuge
  • Norihiro Kokudo
  • Masatoshi Makuuchi
Original Scientific Report

Abstract

Liver metastasis of breast cancer is considered a generalized disease, and surgical treatment is rarely discussed. Thirty-four patients who underwent 35 hepatectomies for liver metastases of breast cancer between 1985 and 2003 were analyzed. The median interval between the breast surgery and relapse in the liver was 1.9 years (0–20 years). The liver was the first site of recurrence in 25 patients. Fifteen clinicopathologic factors were evaluated using univariate and multivariate analyses to predict survival after hepatic resection. No patients died because of the surgery. The median survival was 36 months (1 month to 20 years). The overall and disease-free 5-year survival rates after hepatectomy for breast metastases were 21% and 16%, respectively. Four patients survived more than 5 years. The presence of extrahepatic recurrence prior to hepatectomy was the only significant prognostic factor according to the analyses, and the 5-year survival rate of patients without extrahepatic disease was 31%. No patient who had hilar lymph node metastasis survived more than 5 years. In the absence of extrahepatic recurrence, surgical resection of liver metastasis from breast cancer can offer an acceptable prognosis and should not be avoided in selected patients.

Keywords

Breast Cancer Liver Metastasis Hepatic Resection Invasive Lobular Carcinoma Radical Mastectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported in part by a grant-in-aid for scientific research from the Ministry of Education, Science, and Culture and from the Ministry of Health and Welfare of Japan.

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Copyright information

© Société Internationale de Chirurgie 2005

Authors and Affiliations

  • Yoshihiro Sakamoto
    • 1
  • Junji Yamamoto
    • 2
  • Masataka Yoshimoto
    • 2
  • Fujio Kasumi
    • 2
  • Tomoo Kosuge
    • 1
  • Norihiro Kokudo
    • 3
  • Masatoshi Makuuchi
    • 3
  1. 1.Hepato-Biliary and Pancreatic Surgery Division, Department of SurgeryNational Cancer Center HospitalChuo-kuJapan
  2. 2.Department of SurgeryCancer Institute HospitalToshima-ku,Japan
  3. 3.Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of MedicineUniversity of TokyoBunkyo-kuJapan

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