Liver metastasis of breast cancer is considered a generalized disease, and surgical treatment is rarely discussed. Thirty-four patients who underwent 35 hepatectomies for liver metastases of breast cancer between 1985 and 2003 were analyzed. The median interval between the breast surgery and relapse in the liver was 1.9 years (0–20 years). The liver was the first site of recurrence in 25 patients. Fifteen clinicopathologic factors were evaluated using univariate and multivariate analyses to predict survival after hepatic resection. No patients died because of the surgery. The median survival was 36 months (1 month to 20 years). The overall and disease-free 5-year survival rates after hepatectomy for breast metastases were 21% and 16%, respectively. Four patients survived more than 5 years. The presence of extrahepatic recurrence prior to hepatectomy was the only significant prognostic factor according to the analyses, and the 5-year survival rate of patients without extrahepatic disease was 31%. No patient who had hilar lymph node metastasis survived more than 5 years. In the absence of extrahepatic recurrence, surgical resection of liver metastasis from breast cancer can offer an acceptable prognosis and should not be avoided in selected patients.
Breast Cancer Liver Metastasis Hepatic Resection Invasive Lobular Carcinoma Radical Mastectomy
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.
This work was supported in part by a grant-in-aid for scientific research from the Ministry of Education, Science, and Culture and from the Ministry of Health and Welfare of Japan.
Clark, GM, Sledge, GW,Jr, Osborne, CK, et al. 1987Survival from first recurrence: relative importance of prognostic factors in 1,015 breast cancer patientsJ. Clin. Oncol55561PubMedGoogle Scholar
Insa, A, Lluch, A, Prosper, F, et al. 1999Prognostic factors predicting survival from first recurrence in patients with metastatic breast cancer: analysis of 439 patientsBreast Cancer Res. Treat.566778CrossRefPubMedGoogle Scholar
Inoue, K, Ogawa, M, Horikoshi, N, et al. 1991Evaluation of prognostic factors for 233 patients with recurrent advanced breast cancerJpn. J. Clin. Oncol.21334339PubMedGoogle Scholar
Schneebaum, S, Walker, MJ, Young, D, et al. 1994The regional treatment of liver metastases from breast cancerJ. Surg. Oncol.552632PubMedGoogle Scholar
Selzner, M, Morse, MA, Vredenburgh, JJ, et al. 2000Liver metastases from breast cancer: long-term survival after curative resectionSurgery127383389CrossRefPubMedGoogle Scholar
Elias, D, Maisonnette, F, Druet-Cabanac, M, et al. 2003An attempt to clarify the indications for hepatectomy for liver metastases from breast cancerAm. J. Surg.185158164CrossRefPubMedGoogle Scholar
Yoshimoto, M, Tada, T, Saito, M, et al. 2000Surgical treatment of hepatic metastases from breast cancerBreast Cancer Res. Treat.59177184CrossRefPubMedGoogle Scholar
Pocard, M, Pouillart, P, Asselain, B, et al. 2000Hepatic resection in metastatic breast cancer: results and prognostic factorsEur. J. Surg. Oncol.26155159CrossRefPubMedGoogle Scholar
International Union Against Cancer (UICC)Sobin, LHWittekind, C eds. 2002TNM Classification of Malignant Tumours6Wiley-LissNew YorkGoogle Scholar
Kaplan, EL, Meier, R 1958Nonparametric estimation from incomplete observationsJ. Am. Stat. Assoc.53457481Google Scholar
Cox, DR 1972Regression models and life-tablesJ. R. Stat. Soc.34187220Google Scholar
Koenders, PG, Beex, LV, Kloopenborg, PW, et al. 1992Human breast cancer: survival from first metastasisBreast Cancer Res. Treat.21173180PubMedGoogle Scholar
Yamamoto, J, Shimada, K, Kosuge, T, et al. 1999Factors influencing survival of patients undergoing hepatectomy for colorectal metastasesBr. J. Surg.86332337CrossRefPubMedGoogle Scholar
Minagawa, M, Makuuchi, M, Torzilli, G, et al. 2000Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancerAnn. Surg.231487499CrossRefPubMedGoogle Scholar